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  Mechanobiology of leader–follower dynamics in epithelial cell migration

Vishwakarma, M., Spatz, J. P., & Das, T. (2020). Mechanobiology of leader–follower dynamics in epithelial cell migration. Current Opinion in Cell Biology, 66, 97-103. doi:10.1016/j.ceb.2020.05.007.

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CurrOpinCellBiol_66_2020_97.pdf (Any fulltext), 2MB
 
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 Creators:
Vishwakarma, Medhavi1, Author              
Spatz, Joachim P.1, 2, Author              
Das, Tamal, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: Collective cell migration ; Leader cells ; Mechanobiology ; Jamming
 Abstract: Collective cell migration is fundamental to biological form and function. It is also relevant to the formation and repair of organs and to various pathological situations, including metastatic propagation of cancer. Technological, experimental, and computational advancements have allowed the researchers to explore various aspects of collective migration, spanning from biochemical signalling to inter-cellular force transduction. Here, we summarize our current understanding of the mechanobiology of collective cell migration, limiting to epithelial tissues. On the basis of recent studies, we describe how cells sense and respond to guidance signals to orchestrate various modes of migration and identify the determining factors dictating leader–follower interactions. We highlight how the inherent mechanics of dense epithelial monolayers at multicellular length scale might instruct individual cells to behave collectively. On the basis of these findings, we propose that mechanical resilience, obtained by a certain extent of cell jamming, allows the epithelium to perform efficient collective migration during wound healing.

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Language(s): eng - English
 Dates: 2020-07-112020-10-01
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.ceb.2020.05.007
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Title: Current Opinion in Cell Biology
  Other : Curr. Opin. Cell Biol.
Source Genre: Journal
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Publ. Info: Philadelphia, PA, USA : Elsevier Current Trends
Pages: - Volume / Issue: 66 Sequence Number: - Start / End Page: 97 - 103 Identifier: ISSN: 0955-0674
CoNE: https://pure.mpg.de/cone/journals/resource/954925576019