Sensitivity gain from multi-echo acquisitions in ex-vivo diffusion imaging: 
Numerical simulations and experimental verification

Eichner, Cornelius; Paquette, Michael; Mildner, Toralf; Schlumm, Torsten; Crockford, Catherine; Wittig, Roman M.; Jäger, Carsten; Morawski, Markus; Möller, Harald E.; Friederici, Angela D.; Anwander, Alfred

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Sensitivity gain from multi-echo acquisitions in ex-vivo diffusion imaging: Numerical simulations and experimental verification

Eichner, C., Paquette, M., Mildner, T., Schlumm, T., Crockford, C., Wittig, R. M., et al. (2020). Sensitivity gain from multi-echo acquisitions in ex-vivo diffusion imaging: Numerical simulations and experimental verification. Poster presented at 28th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM), Virtual Conference.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0006-D4D5-A Version Permalink: https://hdl.handle.net/21.11116/0000-0006-D4D6-9

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Creators:
Eichner, Cornelius¹, Author
Paquette, Michael¹, Author
Mildner, Toralf², Author
Schlumm, Torsten², Author
Crockford, Catherine³, Author
Wittig, Roman M.³, Author
Jäger, Carsten⁴, Author
Morawski, Markus⁵, Author
Möller, Harald E.², Author
Friederici, Angela D.¹, Author
Anwander, Alfred¹, Author

Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551
2Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558
3Department of Human Behavior Ecology and Culture, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_2173689
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649
5Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550

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Abstract: Ex-vivo dMRI acquisitions achieve very high resolutions from increased SNR at the cost of prolonged scan times. Due to highly-segmented acquisition strategies, the ex-vivo dMRI signal is often not fully decayed when signal encoding progresses. Using numerical simulations and real-dMRI data from a wild chimpanzee, we show that this circumstance can be effectively employed using an optimized noise informed combination of multi-echo acquisitions from segmented EPI trains. The additional sampling comes at a small price and leads to increased SNR and a general reduction of signal bias.

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Dates: Created: 2020-08-08

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Title: 28th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM)

Place of Event: Virtual Conference

Start-/End Date: 2020-08-08 - 2020-08-14

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