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  The immunogenetics of sexual parasitism

Swann, J., Holland, S. J., Petersen, M., Pietsch, T. W., & Boehm, T. (2020). The immunogenetics of sexual parasitism. Science, 369, 1608-1615. doi:10.1126/science.aaz9445.

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Swann et al..pdf (Publisher version), 2MB
 
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2020
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 Creators:
Swann, Jeremy1, Author              
Holland, Stephen J.1, Author
Petersen, Malte1, Author
Pietsch, Theodore W.2, Author
Boehm, Thomas1, Author              
Affiliations:
1Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              
2External Organizations, ou_persistent22              

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 Abstract: Sexual parasitism has evolved as a unique mode of reproduction among deep-sea anglerfishes. The permanent attachment of males to host females observed in these species represents a form of anatomical joining, which is otherwise unknown in nature. Striking modifications to immune facilities are associated with this reproductive trait. The genomes of species with temporarily attaching males lack functional aicda genes that underpin affinity maturation of antibodies. Permanent attachment is associated with additional alterations, culminating in the loss of functional rag genes in some species, abolishing somatic diversification of antigen receptor genes, the hallmark of canonical adaptive immunity. In anglerfishes, co-evolution of innate and adaptive immunity has been disentangled, implying that an alternative form of immunity supported the emergence of this evolutionarily successful group of vertebrates.

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Language(s): eng - English
 Dates: 2020-07-302020-09-25
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1126/science.aaz9445
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Title: Science
  Other : Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 369 Sequence Number: - Start / End Page: 1608 - 1615 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1