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  Combination of bioresponsive chelates and perfluorinated lipid nanoparticles enables in vivo MRI probe quantification

Gambino, G., Gambino, T., & Angelovski, G. (2020). Combination of bioresponsive chelates and perfluorinated lipid nanoparticles enables in vivo MRI probe quantification. Chemical Communications, 56(66), 9433-9436. doi:10.1039/d0cc04416d.

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Gambino, G1, 2, Author              
Gambino, T1, 2, Author              
Angelovski, G1, 2, Author              
Affiliations:
1Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: We developed a nanosized perfluorocarbon-based system with incorporated paramagnetic Gd(iii) chelates, able to generate a quantitative 19F MRI signal, while in parallel capable of modulating the 1H MRI signal in response to the coordination of Ca2+ ions. Subsequently, we performed experiments in vivo and estimated the concentration of the applied probe in the tissue by means of 19F MRI.

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 Dates: 2020-072020-08
 Publication Status: Published in print
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 Identifiers: DOI: 10.1039/d0cc04416d
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Title: Chemical Communications
  Other : Chem. Commun.
Source Genre: Journal
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Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: - Volume / Issue: 56 (66) Sequence Number: - Start / End Page: 9433 - 9436 Identifier: ISSN: 1359-7345
CoNE: https://pure.mpg.de/cone/journals/resource/954928495413