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  Microstructural organization of human insula is linked to its macrofunctional circuitry and predicts cognitive control

Menon, V., Gallardo, G., Pinsk, M. A., Nguyen, V.-D., Li, J.-R., Cai, W., et al. (2020). Microstructural organization of human insula is linked to its macrofunctional circuitry and predicts cognitive control. eLife, 9: e53470. doi:10.7554/eLife.53470.

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 Creators:
Menon, Vinod1, 2, Author
Gallardo, Guillermo3, 4, Author              
Pinsk, Mark A.5, Author
Nguyen, Van-Dang6, Author
Li, Jing-Rebecca7, Author
Cai, Weidong1, Author
Wassermann, Demian8, Author
Affiliations:
1Department of Psychiatry and Behavioral Sciences, Center for Interdisciplinary Brain Sciences Research, Stanford University School of Medicine, CA, USA, ou_persistent22              
2Wu Tsai Neurosciences Institute, Stanford University, CA, USA, ou_persistent22              
3Centre Inria Sophia Antipolis, University of Côte d'Azur, Valbonne, France, ou_persistent22              
4Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
5Princeton Neuroscience Institute, Princeton University, NJ, USA, ou_persistent22              
6Division of Computational Science and Technology, KTH Royal Institute of Technology, Stockholm, Sweden, ou_persistent22              
7École polytechnique de l'université Paris Sud, France, ou_persistent22              
8Centre Inria Saclay de l'université Paris Sud, France, ou_persistent22              

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Free keywords: Behaviour; Cognitive control; Diffusion MRI; Human; Insula; Neural circuits; Neuroscience; Rhesus macaque; Saliency network
 Abstract: The human insular cortex is a heterogeneous brain structure which plays an integrative role in guiding behavior. The cytoarchitectonic organization of the human insula has been investigated over the last century using postmortem brains but there has been little progress in noninvasive in vivo mapping of its microstructure and large-scale functional circuitry. Quantitative modeling of multi-shell diffusion MRI data from 413 participants revealed that human insula microstructure differs significantly across subdivisions that serve distinct cognitive and affective functions. Insular microstructural organization was mirrored in its functionally interconnected circuits with the anterior cingulate cortex that anchors the salience network, a system important for adaptive switching of cognitive control systems. Furthermore, insular microstructural features, confirmed in Macaca mulatta, were linked to behavior and predicted individual differences in cognitive control ability. Our findings open new possibilities for probing psychiatric and neurological disorders impacted by insular cortex dysfunction, including autism, schizophrenia, and fronto-temporal dementia.

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Language(s): eng - English
 Dates: 2019-11-292020-05-092020-06-22
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.7554/eLife.53470
PMID: 32496190
PMC: PMC7308087
 Degree: -

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Project name : Horizon 2020
Grant ID : SLAB ERC-StG-676943
Funding program : -
Funding organization : European Research Council

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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 9 Sequence Number: e53470 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X