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  Insulin resistance is associated with reduced food odor sensitivity across a wide range of body weights

Poessel, M., Freiherr, J., Wiencke, K., Villringer, A., & Horstmann, A. (2020). Insulin resistance is associated with reduced food odor sensitivity across a wide range of body weights. Nutrients, 12(8): 2201. doi:10.3390/nu12082201.

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 Urheber:
Poessel, Maria1, 2, 3, Autor           
Freiherr, Jessica4, 5, Autor
Wiencke, Kathleen1, 2, 3, 6, Autor
Villringer, Arno2, 6, 7, 8, 9, 10, Autor           
Horstmann, Annette1, 2, 3, 11, Autor           
Affiliations:
1Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
3Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
4Department of Psychology and Psychotherapy, Friedrich Alexander University Erlangen,, ou_persistent22              
5Fraunhofer Institute for Process Engineering and Packaging IVV, Freising, Germany, ou_persistent22              
6International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2616696              
7MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
8Charité University Medicine Berlin, Germany, ou_persistent22              
9Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
10International Max Planck Research School on the Life Course, Max Planck Institute for Human Development, Berlin, Germany, ou_persistent22              
11Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland, ou_persistent22              

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Schlagwörter: Obesity; Odor sensitivity; Olfaction; HOMA-IR; Insulin resistance
 Zusammenfassung: The worldwide obesity epidemic is a major health problem driven by the modern food environment. Recently, it has been shown that smell perception plays a key role in eating behavior and is altered in obesity. However, the underlying mechanisms of this phenomenon are not well understood yet. Since the olfactory system is closely linked to the endocrine system, we hypothesized that hormonal shifts in obesity might explain this relationship. In a within-subject, repeated-measures design, we investigated sensitivity to a food and a non-food odor in the hungry and sated state in 75 young healthy (26 normal weight, 25 overweight, and 24 obese) participants (37 women). To determine metabolic health status and hormonal reactivity in response to food intake, we assessed pre- and postprandial levels of insulin, leptin, glucose, and ghrelin. Odor sensitivity did not directly depend on body weight status/body mass index (BMI) or hunger state. However, we could establish a strong negative mediating effect of insulin resistance on the relationship between BMI/waist-hip ratio and olfactory sensitivity for the food odor. These findings indicate an impact of metabolic health status on sensitivity to food odors. Our results contribute to a better understanding of the mechanisms behind altered smell perception in obesity.

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Sprache(n): eng - English
 Datum: 2020-07-182020-06-262020-07-202020-07-24
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.3390/nu12082201
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Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : IFB Adiposity Diseases
Projektname : -
Grant ID : 01EO1501; 01EA1409G
Förderprogramm : -
Förderorganisation : Federal Ministry of Education and Research (BMBF)
Projektname : CRC 1052 “Obesity Mechanisms”
Grant ID : -
Förderprogramm : (209933838)
Förderorganisation : German Research Foundation (DFG)
Projektname : MultiSense
Grant ID : Attract 023-600814
Förderprogramm : -
Förderorganisation : Fraunhofer-Gesellschaft

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Titel: Nutrients
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: Basel : MDPI
Seiten: - Band / Heft: 12 (8) Artikelnummer: 2201 Start- / Endseite: - Identifikator: ISSN: 2072-6643
CoNE: https://pure.mpg.de/cone/journals/resource/2072-6643