English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Reduction of somatosensory functional connectivity by transcranial alternating current stimulation at endogenous mu-frequency

Gundlach, C., Müller, M. M., Hoff, M., Ragert, P., Nierhaus, T., Villringer, A., et al. (2020). Reduction of somatosensory functional connectivity by transcranial alternating current stimulation at endogenous mu-frequency. NeuroImage, 221: 117175. doi:10.1016/j.neuroimage.2020.117175.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0006-D3DD-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-D3DE-2
Genre: Journal Article

Files

show Files
hide Files
:
Gundlach_Mueller_2020.pdf (Publisher version), 3MB
Name:
Gundlach_Mueller_2020.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Gundlach, Christopher1, 2, Author              
Müller, Matthias M.2, Author
Hoff, Maike1, Author              
Ragert, Patrick1, 3, Author              
Nierhaus, Till1, 4, Author              
Villringer, Arno1, 5, 6, Author              
Sehm, Bernhard1, 6, 7, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
2Institute of Psychology, University of Leipzig, Germany, ou_persistent22              
3Institute of General Kinesiology and Athletics Training, Faculty of Sport Science, University of Leipzig, Germany, ou_persistent22              
4Neurocomputation and Neuroimaging Unit, FU Berlin, Germany, ou_persistent22              
5MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
6Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
7University Hospital, Halle/Saale, Germany, ou_persistent22              

Content

show
hide
Free keywords: tACS; Mu-alpha; Neural oscillations; fMRI; Somatosensory cortex; Brain stimulation
 Abstract: Alpha, the most prominent human brain rhythm, might reflect a mechanism of functional inhibition for gating neural processing. This concept has been derived predominantly from local measures of inhibition, while large-scale network mechanisms to guide information flow are largely unknown. Here, we investigated functional connectivity changes on a whole-brain level by concurrent transcranial alternating current stimulation (tACS) and resting-state functional MRI in humans. We specifically focused on somatosensory alpha-band oscillations by adjusting the tACS frequency to each individual´s somatosensory (mu-) alpha peak frequency (mu-tACS). Potential differences of Eigenvector Centrality of primary somatosensory cortex (S1) as well as on a whole brain level between mu-tACS and sham were analyzed. Our results demonstrate that mu-tACS induces a locally-specific decrease in whole-brain functional connectivity of left S1. An additional exploratory analysis revealed that this effect primarily depends on a decrease in functional connectivity between S1 and a network of regions that are crucially involved in somatosensory processing. Furthermore, the decrease in functional centrality was specific to mu-tACS and was not observed when tACS was applied in the gamma-range in an independent study. Our findings provide evidence that modulated somatosensory (mu-) alpha-activity may affect whole-brain network level activity by decoupling primary sensory areas from other hubs involved in sensory processing.

Details

show
hide
Language(s): eng - English
 Dates: 2020-06-192020-05-292020-07-142020-07-172020-11-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.neuroimage.2020.117175
Other: online ahead of print
PMID: 32682989
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: NeuroImage
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 221 Sequence Number: 117175 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166