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  Distinguish hemodynamic responses at the white matter tract from the laminar-specific gray matter fMRI signal with line-scanning fMRI

Choi, S., Zeng, H., Biswal, B., Rosen, B., & Yu, X. (2020). Distinguish hemodynamic responses at the white matter tract from the laminar-specific gray matter fMRI signal with line-scanning fMRI. In 2020 ISMRM & SMRT Virtual Conference & Exhibition (pp. 496).

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-D7BD-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-E7D4-6
Genre: Meeting Abstract

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 Creators:
Choi, S1, 2, Author              
Zeng, H1, 2, Author              
Biswal, B, Author
Rosen, BR, Author
Yu, X1, 2, Author              
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: We applied line-scanning fMRI to investigate evoked hemodynamic responses in both laminar-specific gray matter (GM) and white matter (WM) in rats. Based on the WM-specific cross-correlation lag time to the laminar-specific fMRI signal, distinct WM hemodynamic responses were characterized across animals, showing a biphasic HRF with earlier lag times and a monophasic HRF with later lag times. Also, the lag-time dependent HRFs were detected in the subcortical area under the WM. Elucidating neurovascular coupling characteristics of distinct WM hemodynamic responses may help understand the progression of WM-related diseases, e.g. multiple sclerosis (MS) or small vessel disease (SVD).

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 Dates: 2020-08
 Publication Status: Published online
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Title: 2020 ISMRM & SMRT Virtual Conference & Exhibition
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Start-/End Date: 2020-08-08 - 2020-08-14

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Title: 2020 ISMRM & SMRT Virtual Conference & Exhibition
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 1354 Start / End Page: 496 Identifier: -