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  The peripartum human brain: Current understanding and future perspectives

Sacher, J., Chechko, N., Dannlowski, U., Walter, M., & Derntl, B. (2020). The peripartum human brain: Current understanding and future perspectives. Frontiers in Neuroendocrinology, 100859. doi:10.1016/j.yfrne.2020.100859.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-D86B-F Version Permalink: http://hdl.handle.net/21.11116/0000-0006-D86C-E
Genre: Journal Article

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 Creators:
Sacher, Julia1, Author              
Chechko, Natalia2, Author
Dannlowski, Udo3, Author
Walter, Martin4, Author
Derntl, Birgit5, Author
Affiliations:
1Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3230775              
2Research Center Jülich, Germany, ou_persistent22              
3Department of Psychiatry and Psychotherapy, University Hospital Münster, Germany, ou_persistent22              
4Institute of Psychosocial Medicine and Psychotherapy, Jena University Hospital, Germany, ou_persistent22              
5Department for Psychiatry and Psychotherapy, Eberhard Karls University Tübingen, Germany, ou_persistent22              

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Free keywords: MR; PET; Female mental health; Neuroimaging; Peripartum depression; Reproductive psychiatry
 Abstract: The peripartum period offers a unique opportunity to improve our understanding of how dramatic fluctuations in endogenous ovarian hormones affect the human brain and behavior. This notwithstanding, peripartum depression remains an underdiagnosed and undertreated disorder. Here, we review recent neuroimaging findings with respect to the neuroplastic changes in the maternal brain during pregnancy and the postpartum period. We seek to provide an overview of multimodal neuroimaging designs of current peripartum depression models of hormone withdrawal, changes in monoaminergic signaling, and maladaptive neuroplasticity, which likely lead to the development of a condition that puts the lives of mother and infant at risk. We discuss the need to effectively integrate the available information on psychosocial and neurobiological risk factors contributing to individual vulnerability. Finally, we propose a systematic approach to neuroimaging the peripartum brain that acknowledges important co-morbidities and variation in disease onset.

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Language(s): eng - English
 Dates: 2020-06-302020-02-142020-07-312020-08-06
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.yfrne.2020.100859
Other: online ahead of print
PMID: 32771399
 Degree: -

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Title: Frontiers in Neuroendocrinology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Orlando, Fla. : Academic Press
Pages: - Volume / Issue: - Sequence Number: 100859 Start / End Page: - Identifier: ISSN: 0091-3022
CoNE: https://pure.mpg.de/cone/journals/resource/954922647073