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  Influence of formalin-based fixatives on the MR properties of whole post-mortem pig brains

Nazemorroaya, A., Aghaeifar, A., Schulz, H., Shiozawa-Bayer, T., Hirt, B., Scheffler, K., et al. (2020). Influence of formalin-based fixatives on the MR properties of whole post-mortem pig brains. Poster presented at 2020 ISMRM & SMRT Virtual Conference & Exhibition.

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Nazemorroaya, A1, 2, Author              
Aghaeifar, A1, 2, Author              
Schulz, H1, 2, Author              
Shiozawa-Bayer, T, Author
Hirt, B, Author
Scheffler, K1, 2, Author              
Hagberg, G1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Post-mortem brain MRI can yield valuable information. However, tissue preservation and MR-compatibility of fixation agents are challenging. Here we investigated the effect of four MR-compatible formalin-based fixatives on the MR properties of pig brains at several timepoints after start of fixation up to one month. The inclusion agents known to improve the dielectric properties of the fixatives lead to greater R2* difference between GM-WM than conventional fixatives. Vice versa these agents lead to a decrease in T1 contrast.

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 Dates: 2020-08
 Publication Status: Published online
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Title: 2020 ISMRM & SMRT Virtual Conference & Exhibition
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Start-/End Date: 2020-08-08 - 2020-08-14

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Title: 2020 ISMRM & SMRT Virtual Conference & Exhibition
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 4711 Start / End Page: - Identifier: -