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Abstract:
CEST MRI provides metabolite-based contrasts but often suffers from poor volume coverage or spatial resolution. We optimized and included a snapshot 3D-EPI readout and propose a suitable post-processing pipeline to generate CEST contrast in the whole brain at clinical B0=3T. It is shown that CEST MRI with 1.8mm isotropic nominal resolution at a field of view of 256x224x156mm³ is feasible within 4.3s per presaturation frequency offset. The approach is adaptable for any presaturation scheme. Exemplarily low power saturation was performed and fitted Lorentzian amplitudes gave a coefficient of variation <8.5% across three healthy subjects.
