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  Intranasal oxytocin modulates brain responses to voice-identity recognition in typically developing individuals, but not in ASD

Borowiak, K., & von Kriegstein, K. (2020). Intranasal oxytocin modulates brain responses to voice-identity recognition in typically developing individuals, but not in ASD. Translational Psychiatry, 10(1): 221. doi:10.1038/s41398-020-00903-5.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-D955-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-D956-5
Genre: Journal Article

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Borowiak, Kamila1, 2, 3, Author              
von Kriegstein, Katharina1, 2, Author              
Affiliations:
1TU Dresden, Germany, ou_persistent22              
2Max Planck Research Group Neural Mechanisms of Human Communication, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634556              
3Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              

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 Abstract: Faces and voices are prominent cues for person-identity recognition. Face recognition behavior and associated brain responses can be enhanced by intranasal administration of oxytocin. It is unknown whether oxytocin can also augment voice-identity recognition mechanisms. To find it out is particularly relevant for individuals who have difficulties recognizing voice identity such as individuals diagnosed with autism spectrum disorder (ASD). We conducted a combined behavioral and functional magnetic resonance imaging (fMRI) study to investigate voice-identity recognition following intranasal administration of oxytocin or placebo in a group of adults diagnosed with ASD (full-scale intelligence quotient > 85) and pairwise-matched typically developing (TD) controls. A single dose of 24 IU oxytocin was administered in a randomized, double-blind, placebo-controlled and cross-over design. In the control group, but not in the ASD group, administration of oxytocin compared to placebo increased responses to recognition of voice identity in contrast to speech in the right posterior superior temporal sulcus/gyrus (pSTS/G) - a region implicated in the perceptual analysis of voice-identity information. In the ASD group, the right pSTS/G responses were positively correlated with voice-identity recognition accuracy in the oxytocin condition, but not in the placebo condition. Oxytocin did not improve voice-identity recognition performance at the group level. The ASD compared to the control group had lower right pSTS/G responses to voice-identity recognition. Since ASD is known to have atypical pSTS/G, the results indicate that the potential of intranasal oxytocin to enhance mechanisms for voice-identity recognition might be variable and dependent on the functional integrity of this brain region.

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Language(s): eng - English
 Dates: 2020-06-052019-10-102020-06-082020-07-07
 Publication Status: Published online
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 Identifiers: DOI: 10.1038/s41398-020-00903-5
PMID: 32636360
PMC: PMC7341857
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Title: Translational Psychiatry
  Abbreviation : Transl Psychiatry
Source Genre: Journal
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Publ. Info: Nature Pub. Group
Pages: - Volume / Issue: 10 (1) Sequence Number: 221 Start / End Page: - Identifier: ISSN: 2158-3188
CoNE: https://pure.mpg.de/cone/journals/resource/2158-3188