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  Lipid-protein interactions modulate the conformational equilibrium of a potassium channel

Gu, R. X., & de Groot, B. L. (2020). Lipid-protein interactions modulate the conformational equilibrium of a potassium channel. Nature Communications, 11: 2162. doi:10.1038/s41467-020-15741-8.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-DAAB-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-03C6-6
Genre: Journal Article

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 Creators:
Gu, R. X.1, Author              
de Groot, B. L.1, Author              
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1Research Group of Computational Biomolecular Dynamics, MPI for biophysical chemistry, Max Planck Society, ou_578573              

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 Abstract: Cell membranes actively participate in the regulation of protein structure and function. In this work, we conduct molecular dynamics simulations to investigate how different membrane environments affect protein structure and function in the case of MthK, a potassium channel. We observe different ion permeation rates of MthK in membranes with different properties, and ascribe them to a shift of the conformational equilibrium between two states of the channel that differ according to whether a transmembrane helix has a kink. Further investigations indicate that two key residues in the kink region mediate a crosstalk between two gates at the selectivity filter and the central cavity, respectively. Opening of one gate eventually leads to closure of the other. Our simulations provide an atomistic model of how lipid-protein interactions affect the conformational equilibrium of a membrane protein. The gating mechanism revealed for MthK may also apply to other potassium channels.

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Language(s): eng - English
 Dates: 2020-05-01
 Publication Status: Published online
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-020-15741-8
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Title: Nature Communications
Source Genre: Journal
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Pages: 10 Volume / Issue: 11 Sequence Number: 2162 Start / End Page: - Identifier: -