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  Perturbation of the right prefrontal cortex disrupts interference control

Friehs, M., Klaus, J., Singh, T., Frings, C., & Hartwigsen, G. (2020). Perturbation of the right prefrontal cortex disrupts interference control. NeuroImage, 222: 117279. doi:10.1016/j.neuroimage.2020.117279.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-DCDA-D Version Permalink: http://hdl.handle.net/21.11116/0000-0006-F019-F
Genre: Journal Article

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 Creators:
Friehs, Maximilian1, Author
Klaus, Jana2, Author
Singh, Tarini3, Author
Frings, Christian1, Author
Hartwigsen, Gesa4, Author              
Affiliations:
1Department of Cognitive Psychology and Methodology, University of Trier, Germany, ou_persistent22              
2Department of Experimental Psychology, Utrecht University, the Netherlands, ou_persistent22              
3Department of Experimental Psychology, Martin Luther University Halle-Wittenberg, Germany, ou_persistent22              
4Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025665              

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Free keywords: Adaptive control; Cognitive control; Dorsolateral prefrontal cortex; Repetative transcranial magnetic stimulation; Stroop; TMS
 Abstract: Resolving cognitive interference is central for successful everyday cognition and behavior. The Stroop task is a classical measure of cognitive interference. In this task, participants have to resolve interference on a trial-by-trial basis and performance is also influenced by the trial history, as reflected in sequence effects. Previous neuroimaging studies have associated the left and right prefrontal cortex with successful performance in the Stroop task. Yet, the causal relevance of both regions for interference processing remains largely unclear. We probed the functional relevance of the left and right prefrontal cortex for interference control. In three sessions, 25 healthy participants received online repetitive transcranial magnetic stimulation (rTMS) over the left and right dorsolateral prefrontal cortex, and sham stimulation over the vertex. During each session, participants completed a verbal-response Stroop task. Relative to sham rTMS and rTMS over the left prefrontal cortex, rTMS over the right prefrontal cortex selectively disrupted the Stroop sequence effect (i.e., the congruency sequence effect; CSE). This effect was specific to sequential modulations of interference since rTMS did not affect the Stroop performance in the ongoing trial. Our results demonstrate the functional relevance of the right dorsolateral prefrontal cortex for the processing of interference control. This finding points towards process-specific lateralization within the prefrontal cortex. The observed process- and site-specific TMS effect provides new insights into the neurophysiological underpinnings of Stroop task performance and more general, the role of the prefrontal cortex in the processing of interference control.

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Language(s): eng - English
 Dates: 2020-08-112020-05-202020-08-142020-08-212020-11-15
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2020.117279
Other: online ahead of print
PMID: 32828926
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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 222 Sequence Number: 117279 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166