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  Orthogonally protected building blocks for automated glycan assembly

Pfrengle, F., & Seeberger, P. H. (2018). Orthogonally protected building blocks for automated glycan assembly. In Protecting Groups (pp. 451-471). Weinheim: Wiley-VCH.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-DB42-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-E777-0
Genre: Book Chapter

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 Creators:
Pfrengle, Fabian1, Author              
Seeberger, Peter H.2, Author              
Affiliations:
1Fabian Pfrengle, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863303              
2Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              

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Free keywords: solid-phase oligosaccharide synthesis, automated glycan assembly, orthogonally protected building blocks
 Abstract: Summary Following an introduction to solid-phase carbohydrate chemistry and automated glycan assembly, we discuss the specific requirements for protecting groups (PGs) used in solid-phase chemistry. Besides routinely applied permanent and temporary PGs, specialized solutions for specific problems such as the introduction of β-mannosides are covered. Based on the available orthogonal PGs, a general strategy for the design of suitable building blocks for a given oligosaccharide target is proposed. A set of “approved” monosaccharide building blocks that have been successfully applied in the assembly of various oligosaccharides is presented. Exemplary syntheses of mammalian, microbial, and plant oligosaccharides are described to demonstrate the importance of choosing suitable orthogonally protected building blocks. Finally, an update on commercial automated oligosaccharide synthesizers is provided as well as a short outlook on the chances and challenges of automated glycan assembly.

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 Dates: 2018
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/9783527697014.ch16
BibTex Citekey: doi:10.1002/9783527697014.ch16
 Degree: -

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Title: Protecting Groups
Source Genre: Book
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Publ. Info: Weinheim : Wiley-VCH
Pages: 502 S. Volume / Issue: - Sequence Number: - Start / End Page: 451 - 471 Identifier: ISBN: 9783527697014