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  Cerebellar circuitry and auditory verbal hallucinations: An integrative synthesis and perspective

Pinheiro, A. P., Schwartze, M., & Kotz, S. A. (2020). Cerebellar circuitry and auditory verbal hallucinations: An integrative synthesis and perspective. Neuroscience and Biobehavioral Reviews. doi:10.1016/j.neubiorev.2020.08.004.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-E73C-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-E73D-2
Genre: Journal Article

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 Creators:
Pinheiro, Ana P.1, 2, Author
Schwartze, Michael2, Author
Kotz, Sonja A.2, 3, Author              
Affiliations:
1Faculty of Psychology, University of Lisbon, Portugal, ou_persistent22              
2Department of Neuropsychology and Psychopharmacology, Maastricht University, the Netherlands, ou_persistent22              
3Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Free keywords: Auditory verbal hallucinations; Forward model; Cerebellum; Cognition; Psychosis continuum
 Abstract: Auditory verbal hallucinations (AVH) ― experienced as voice hearing independent of a corresponding external sound source ― are a cardinal symptom of psychosis. Approximately 6-13% of healthy individuals also experience voice hearing. Despite numerous attempts to explain the neurofunctional mechanisms underlying AVH, they remain notoriously unexplained. However, evidence relates AVH to mechanistic changes in the forward model. This review synthesizes behavioral and neuroimaging studies exploring the central role of cerebellar circuitry in the forward model, with a particular focus on non-verbal and verbal auditory feedback. It confirms that erratic prediction of sensory consequences in voice and sound production is linked to impaired cerebellar function, which initiates AVH and affects higher-level cognitive functions. We propose new research directions linking the forward model to voice and sound feedback processing. We consider this review as a starting point for mapping mechanisms of the forward model to neurocognitive mechanisms underlying AVH.

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Language(s): eng - English
 Dates: 2020-06-302020-02-072020-08-072020-08-15
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neubiorev.2020.08.004
Other: online ahead of print
PMID: 32810512
 Degree: -

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Title: Neuroscience and Biobehavioral Reviews
Source Genre: Journal
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Publ. Info: New York [etc.] : Pergamon
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0149-7634
CoNE: https://pure.mpg.de/cone/journals/resource/954928536106