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  SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Braun, J., Loyal, L., Frentsch, M., Wendisch, D., Georg, P., Kurth, F., et al. (2020). SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19. Nature, 2020. doi:10.1038/s41586-020-2598-9.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-EAC4-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-EAC5-4
Genre: Journal Article

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 Creators:
Braun, Julian, Author
Loyal, Lucie , Author
Frentsch, Marco , Author
Wendisch, Daniel , Author
Georg, Philipp, Author
Kurth, Florian, Author
Hippenstiel, Stefan, Author
Dingeldey, Manuela, Author
Kruse, Beate, Author
Fauchere, Florent, Author
Baysal, Emre, Author
Mangold, Maike, Author
Henze, Larissa, Author
Lauster, Roland, Author
Mall, Marcus A., Author
Beyer, Kirsten, Author
Röhmel, Jobst, Author
Voigt, Sebastian, Author
Schmitz, Jürgen, Author
Miltenyi, Stefan, Author
Demuth, Ilja, AuthorMüller, Marcel A., AuthorHocke, Andreas, AuthorWitzenrath, Martin, AuthorSuttorp, Norbert, AuthorKern, Florian, AuthorReimer, Ulf, AuthorWenschuh, Holger, AuthorDrosten, Christian, AuthorCorman, Victor M., AuthorGiesecke-Thiel, Claudia1, Author              Sander, Leif Erik, AuthorThiel, Andreas, Author more..
Affiliations:
1Flow Cytometry Facility (Head: Claudia Giesecke-Thiel), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_3039333              

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 Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the rapidly unfolding coronavirus disease 2019 (COVID-19) pandemic1,2. Clinical manifestations of COVID-19 vary, ranging from asymptomatic infection to respiratory failure. The mechanisms determining such variable outcomes remain unresolved. Here, we investigated SARS-CoV-2 spike glycoprotein (S)-reactive CD4+ T cells in peripheral blood of patients with COVID-19 and SARS-CoV-2-unexposed healthy donors (HD). We detected SARS-CoV-2 S-reactive CD4+ T cells in 83% of patients with COVID-19 but also in 35% of HD. S-reactive CD4+ T cells in HD reacted primarily to C-terminal S epitopes, which show a higher homology to spike glycoproteins of human endemic coronaviruses, compared to N-terminal epitopes. S-reactive T cell lines generated from SARS-CoV-2-naive HD responded similarly to C-terminal S of human endemic coronaviruses 229E and OC43 and SARS-CoV-2, demonstrating the presence of S-cross-reactive T cells, probably generated during past encounters with endemic coronaviruses. The role of pre-existing SARS-CoV-2 cross-reactive T cells for clinical outcomes remains to be determined in larger cohorts. However, the presence of S-cross-reactive T cells in a sizable fraction of the general population may affect the dynamics of the current pandemic, and has important implications for the design and analysis of upcoming COVID-19 vaccine trials.

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Language(s): eng - English
 Dates: 2020-07-222020-07-29
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41586-020-2598-9
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 2020 Sequence Number: - Start / End Page: - Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238