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  Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution

Golubev, A., Fatkhullin, B., Khusainov, I., Jenner, L., Gabdulkhakov, A., Validov, S., et al. (2020). Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution. FEBS Letters, 594(21), 3551-3567. doi:10.1002/1873-3468.13915.

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 Creators:
Golubev, Alexander1, 2, Author
Fatkhullin, Bulat1, 3, Author
Khusainov, Iskander1, 4, Author           
Jenner, Lasse2, Author
Gabdulkhakov, Azat1, 3, Author
Validov, Shamil1, Author
Yusupova, Gulnara2, Author
Yusupov, Marat1, 2, Author
Usachev, Konstantin1, Author
Affiliations:
1Laboratory of Structural Biology, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation, ou_persistent22              
2Département de Biologie et de Génomique Structurales, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, Illkirch, France, ou_persistent22              
3Institute of Protein Research, Russian Academy of Sciences, Puschino, Moscow Region, Russian Federation, ou_persistent22              
4Department of Molecular Sociology, Max Planck Institute of Biophysics, Max Planck Society, ou_3040395              

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Free keywords: antibiotic resistance, drug targets, methyltransferases, Ribosome, rRNA modifications, Staphylococcus aureus
 Abstract: Staphylococcus aureus is a bacterial pathogen and one of the leading causes of healthcare-acquired infections in the world. The growing antibiotic resistance of S. aureus obliges us to search for new drugs and treatments. As the majority of antibiotics target the ribosome, knowledge of its detailed structure is crucial for drug development. Here, we report the Cryo-EM reconstruction at 3.2 Å resolution of the S. aureus ribosome with P-site tRNA, messenger RNA and ten RNA modification sites previously not assigned or visualized. The resulting model is the most precise and complete high-resolution structure to date of the S. aureus 70S ribosome with functional ligands.

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Language(s): eng - English
 Dates: 2020-08-112020-07-102020-08-172020-09-102020-11
 Publication Status: Issued
 Pages: 17
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/1873-3468.13915
BibTex Citekey: golubev_cryo-em_2020
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Title: FEBS Letters
  Other : FEBS Lett.
Source Genre: Journal
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Publ. Info: Wiley
Pages: - Volume / Issue: 594 (21) Sequence Number: - Start / End Page: 3551 - 3567 Identifier: ISSN: 0014-5793
CoNE: https://pure.mpg.de/cone/journals/resource/954925399501