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  Predictors of training-related improvement in visuomotor performance in patients with multiple sclerosis: A behavioural and MRI study

Lipp, I., Foster, C., Stickland, R., Sgarlata, E., Tallantyre, E. C., Davidson, A. E., et al. (2020). Predictors of training-related improvement in visuomotor performance in patients with multiple sclerosis: A behavioural and MRI study. Multiple Sclerosis Journal. doi:10.1177/1352458520943788.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-ED9F-D Version Permalink: http://hdl.handle.net/21.11116/0000-0006-EDA0-A
Genre: Journal Article

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 Creators:
Lipp, Ilona1, 2, 3, Author              
Foster, Catherine2, Author
Stickland, Rachael2, Author
Sgarlata, Eleonora1, 2, Author
Tallantyre, Emma C.1, 4, Author
Davidson, Alison E.1, 2, Author
Robertson, Neil P.4, Author
Jones, Derek K.2, Author
Wise, Richard G.2, 5, Author
Tomassini, Valentina1, 2, 4, 5, Author
Affiliations:
1Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, United Kingdom, ou_persistent22              
2Brain Research Imaging Centre, School of Psychology, Cardiff University, United Kingdom, ou_persistent22              
3Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
4Helen Durham Centre for Neuroinflammatory Disease, University Hospital of Wales, Cardiff, United Kingdom, ou_persistent22              
5Institute of Advanced Biomedical Technologies (ITAB), Gabriele D'Annunzio University, Chieti-Pescara, Italy, ou_persistent22              

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Free keywords: Multiple sclerosis; Brain plasticity; Predictors; Functional recovery; MRI; Cognition; Disease-modifying treatment
 Abstract: Background: The development of tailored recovery-oriented strategies in multiple sclerosis requires early identification of an individual’s potential for functional recovery. Objective: To identify predictors of visuomotor performance improvements, a proxy of functional recovery, using a predictive statistical model that combines demographic, clinical and magnetic resonance imaging (MRI) data. Methods: Right-handed multiple sclerosis patients underwent baseline disability assessment and MRI of the brain structure, function and vascular health. They subsequently undertook 4 weeks of right upper limb visuomotor practice. Changes in performance with practice were our outcome measure. We identified predictors of improvement in a training set of patients using lasso regression; we calculated the best performing model in a validation set and applied this model to a test set. Results: Patients improved their visuomotor performance with practice. Younger age, better visuomotor abilities, less severe disease burden and concurrent use of preventive treatments predicted improvements. Neuroimaging localised outcome-relevant sensory motor regions, the microstructure and activity of which correlated with performance improvements. Conclusion: Initial characteristics, including age, disease duration, visuo-spatial abilities, hand dexterity, self-evaluated disease impact and the presence of disease-modifying treatments, can predict functional recovery in individual patients, potentially improving their clinical management and stratification in clinical trials. MRI is a correlate of outcome, potentially supporting individual prognosis.

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Language(s): eng - English
 Dates: 2020-08-04
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1177/1352458520943788
Other: online ahead of print
PMID: 32749927
 Degree: -

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Title: Multiple Sclerosis Journal
Source Genre: Journal
 Creator(s):
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Publ. Info: London : Sage
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1477-0970
CoNE: https://pure.mpg.de/cone/journals/resource/1477-0970