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  A novel method to measure T1-relaxation times of macromolecules and quantification of the macromolecular resonances

Murali-Manohar, S., Wright, A., Borbath, T., Avdievich, N., & Henning, A. (2020). A novel method to measure T1-relaxation times of macromolecules and quantification of the macromolecular resonances. Magnetic Resonance in Medicine, Epub ahead. doi:10.1002/mrm.28484.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-EFD6-C Version Permalink: http://hdl.handle.net/21.11116/0000-0006-EFD9-9
Genre: Journal Article

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Murali-Manohar, S1, 2, Author              
Wright, AM1, 2, Author              
Borbath, T1, 2, Author              
Avdievich, NI1, 2, Author              
Henning, A1, 2, Author              
Affiliations:
1Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Purpose: Macromolecular peaks underlying metabolite spectra influence the quantification of metabolites. Therefore, it is important to understand the extent of contribution from macromolecules (MMs) in metabolite quantification. However, to model MMs more accurately in spectral fitting, differences in T1 relaxation times among individual MM peaks must be considered. Characterization of T1 -relaxation times for all individual MM peaks using a single inversion recovery technique is difficult due to eventual contributions from metabolites. On the contrary, a double inversion recovery (DIR) technique provided flexibility to acquire MM spectra spanning a range of longitudinal magnetizations with minimal metabolite influence. Thus, a novel method to determine T1 -relaxation times of individual MM peaks is reported in this work. Methods: Extensive Bloch simulations were performed to determine inversion time combinations for a DIR technique that yielded adequate MM signal with varying longitudinal magnetizations while minimizing metabolite contributions. MM spectra were acquired using DIR-metabolite-cycled semi-LASER sequence. LCModel concentrations were fitted to the DIR signal equation to calculate T1 -relaxation times. Results: T1 -relaxation times of MMs range from 204 to 510 ms and 253 to 564 ms in gray- and white-matter rich voxels respectively at 9.4T. Additionally, concentrations of 13 MM peaks are reported. Conclusion: A novel DIR method is reported in this work to calculate T1 -relaxation times of MMs in the human brain. T1 -relaxation times and relaxation time corrected concentrations of individual MMs are reported in gray- and white-matter rich voxels for the first time at 9.4T.

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 Dates: 2020-08
 Publication Status: Published online
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 Identifiers: DOI: 10.1002/mrm.28484
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: Epub ahead Sequence Number: - Start / End Page: - Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149