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  Quantitative susceptibility mapping in β-Amyloid PET-stratified patients with dementia and healthy controls: A hybrid PET/MRI study

Tiepolt, S., Rullmann, M., Jochimsen, T. H., Gertz, H.-J., Schroeter, M. L., Patt, M., et al. (2020). Quantitative susceptibility mapping in β-Amyloid PET-stratified patients with dementia and healthy controls: A hybrid PET/MRI study. European Journal of Radiology, 131: 109243. doi:10.1016/j.ejrad.2020.109243.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-F2E9-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-0534-9
Genre: Journal Article

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 Creators:
Tiepolt, Solveig1, Author
Rullmann, Michael1, 2, Author              
Jochimsen, Thies H.1, Author
Gertz, Hermann-Josef3, Author
Schroeter, Matthias L.2, Author              
Patt, Marianne1, Author
Sabri, Osama1, Author
Barthel, Henryk1, Author
Affiliations:
1Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Department of Psychiatry, University of Leipzig, Germany, ou_persistent22              

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Free keywords: QSM; Alzheimer’s disease; Dementia; 3T MRI; Iron accumulation; Amyloid-PET
 Abstract: Purpose Post-mortem and in-vivo MRI data suggest an accumulation of iron in the brain of Alzheimer’s disease (AD) patients. The majority of studies in clinically diagnosed AD patients found an increase of iron-sensitive MRI signals in the putamen. As the clinical diagnosis shows only a moderate sensitivity, Aβ-PET was used to further stratify patients with the clinical diagnosis of AD. Aim of this exploratory study was to examine whether Aβ-positive (AD) and Aβ-negative (non-AD) patients differ in their regional magnetic susceptibility compared to healthy controls (HCs) and whether regional susceptibility values correlate with mini mental state examination (MMSE) scores or global Aβ-load. Methods We retrospectively analyzed [11C]PiB PET/MRI data of 11 HCs, 16 AD and 10 non-AD patients. We used quantitative susceptibility mapping (QSM) as iron-sensitive MRI signal measured at the 3 T PET/MR scanner. Global cerebral Aβ-load was determined by composite [11C]PiB SUV ratios. Results Compared to HCs, AD patients showed higher QSM values in putamen (0.049 ± 0.033 vs. 0.002 ± 0.031; p = 0.006), while non-AD patients showed lower QSM values in caudate nucleus (0.003 ± 0.027 vs. 0.051 ± 0.039; p = 0.006). There was a trend towards a significant correlation between putaminal QSM and MMSE values (ρ=-0.340, p = 0.053). In AD patients, global Aβ-load and putaminal QSM values were significantly correlated (ρ=-0.574, p = 0.020). Conclusions These data indicate that AD and non-AD patients may show different cerebral iron pathologies which might be detectable by QSM MRI, and might be linked to neurodegeneration. Overall, the data encourage further investigations in well-defined patient cohorts to clarify the value of QSM/magnetic susceptibility in the course of neurodegenerative diseases and its potential as diagnostic biomarker.

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Language(s): eng - English
 Dates: 2020-07-232019-10-282020-08-112020-08-29
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.ejrad.2020.109243
Other: online ahead of print
PMID: 32916411
 Degree: -

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Title: European Journal of Radiology
  Other : Eur. J. Radiol.
Source Genre: Journal
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Publ. Info: Stuttgart : Elsevier
Pages: - Volume / Issue: 131 Sequence Number: 109243 Start / End Page: - Identifier: ISSN: 0720-048X
CoNE: https://pure.mpg.de/cone/journals/resource/954925532999