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  The hippocampus maps concept space, not feature space

Theves, S., Fernández, G., & Doeller, C. F. (2020). The hippocampus maps concept space, not feature space. The Journal of Neuroscience, 40(38), 7318-7325. doi:10.1523/JNEUROSCI.0494-20.2020.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0006-F948-1 Version Permalink: https://hdl.handle.net/21.11116/0000-000B-4B72-1
Genre: Journal Article

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Theves-J-Neurosci-2020-The Hippocampus Maps Concept Space.pdf (Publisher version), 879KB
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 Creators:
Theves, Stephanie1, 2, Author           
Fernández, Guillén2, Author
Doeller, Christian F.1, 3, Author           
Affiliations:
1Department Psychology (Doeller), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2591710              
2Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
3Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, Kavli Institute, Norwegian University of Science and Technology, Trondheim, Norway, ou_persistent22              

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 Abstract: The hippocampal formation encodes maps of space and a key question in neuroscience is whether its spatial coding principles also provide a universal metric for the organization of non-spatial, conceptual information. Previous work demonstrated directional coding during navigation through a continuous stimulus feature space as well as mapping of distances in a feature space that was relevant for concept learning. Here we provide the first unambiguous evidence for a hippocampal representation of the actual concept space, by showing that the hippocampal distance signal selectively reflects the mapping of specifically conceptually relevant rather than of all feature dimensions. During fMRI scanning of 32 human participants (21 females), we presented every-day objects, which had beforehand been associated with specific values on three continuous feature dimensions. Crucially, only two dimensions were relevant to prior concept learning. We find that hippocampal responses to the objects reflect their relative distances in a space defined along conceptually relevant dimensions as compared to distances in a space defined along all feature dimensions. These findings suggest that the hippocampus supports knowledge acquisition by dynamically encoding information in a space spanned along dimensions that are relevant in relation to define concepts.Statement of significanceHow are neural representations of conceptual knowledge organized, such that humans are able to infer never experienced relations or categorize new exemplars? Map-like representations as supported by the hippocampal formation to encode physical space during navigation have been suggested as a suitable format. Here we provide the first evidence for a hippocampal representation of a conceptual space as compared to a general feature-based space.

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Language(s): eng - English
 Dates: 2020-07-142020-03-012020-07-152020-08-212020-09-16
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1523/JNEUROSCI.0494-20.2020
Other: epub 2020
PMID: 32826311
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Project name : -
Grant ID : 024-001-006
Funding program : -
Funding organization : Netherlands Organisation for Scientific Research
Project name : -
Grant ID : ERC-CoG
Funding program : -
Funding organization : Max Planck Society
Project name : -
Grant ID : GEOCOG
Funding program : -
Funding organization : Kavli Foundation
Project name : -
Grant ID : 724836
Funding program : -
Funding organization : European Research Council
Project name : Centre for Neural Computation
Grant ID : 223262/F50
Funding program : -
Funding organization : Research Council of Norway
Project name : NORBRAIN
Grant ID : 197467/F50
Funding program : -
Funding organization : Research Council of Norway
Project name : -
Grant ID : NWO-Vidi 452-12-009
Funding program : -
Funding organization : Netherlands Organisation for Scientific Research
Project name : -
Grant ID : NWO-MaGW 406-14-114
Funding program : -
Funding organization : Netherlands Organisation for Scientific Research
Project name : -
Grant ID : NWO-MaGW 406-15-291
Funding program : -
Funding organization : Netherlands Organisation for Scientific Research

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Title: The Journal of Neuroscience
  Other : The Journal of Neuroscience: the Official Journal of the Society for Neuroscience
  Abbreviation : J. Neurosci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, DC : Society of Neuroscience
Pages: - Volume / Issue: 40 (38) Sequence Number: - Start / End Page: 7318 - 7325 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1