English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Single-vessel cerebral blood flow fMRI to map blood velocity by phase-contrast imaging

Chen, X., Jiang, Y., Choi, S., Pohmann, R., Scheffler, K., Kleinfeld, D., et al. (submitted). Single-vessel cerebral blood flow fMRI to map blood velocity by phase-contrast imaging.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0006-FBE1-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-FBE7-B
Genre: Paper

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Chen, X1, 2, Author              
Jiang, Y, Author              
Choi, S1, 2, Author              
Pohmann, R2, 3, Author              
Scheffler, K2, 3, Author              
Kleinfeld, D, Author
Yu, X1, 2, Author              
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

Content

show
hide
Free keywords: -
 Abstract: Current approaches to high-field fMRI provide two means to map hemodynamics at the level of single vessels in the brain. One is through changes in deoxyhemoglobin in venules, i.e., blood oxygenation level-dependent (BOLD) fMRI, while the second is through changes in arteriole diameter, i.e., cerebral blood volume (CBV) fMRI. Here we introduce cerebral blood flow (CBF)-fMRI, which uses high-resolution phase-contrast MRI to form velocity measurements of flow and demonstrate CBF-fMRI in single penetrating microvessels across rat parietal cortex. In contrast to the venule-dominated BOLD and arteriole-dominated CBV fMRI signal, the phase-contrast -based CBF signal changes are highly comparable from both arterioles and venules. Thus, we have developed a single-vessel fMRI platform to map the BOLD, CBV, and CBF from penetrating microvessels throughout the cortex. This high-resolution single-vessel fMRI mapping scheme not only enables the vessel-specific hemodynamic mapping in diseased animal models but also presents a translational potential to map vascular dementia in diseased or injured human brains with ultra-high field fMRI. Summary We established a high-resolution PC-based single-vessel velocity mapping method using the high field MRI. This PC-based micro-vessel velocity measurement enables the development of the single-vessel CBF-fMRI method. In particular, in contrast to the arteriole-dominated CBV and venule-dominated BOLD responses, the CBF-fMRI shows similar velocity changes in penetrating arterioles and venules in activated brain regions. Thus, we have built a noninvasive single-vessel fMRI mapping scheme for BOLD, CBV, and CBF hemodynamic parameter measurements in animals.

Details

show
hide
Language(s):
 Dates: 2020-09
 Publication Status: Submitted
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1101/2020.09.03.280636
 Degree: -

Event

show

Legal Case

show

Project information

show

Source

show