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  Assessment of single-vessel cerebral blood velocity by phase contrast fMRI

Chen, X., Jiang, Y., Choi, S., Pohmann, R., Scheffler, K., Kleinfeld, D., et al. (2021). Assessment of single-vessel cerebral blood velocity by phase contrast fMRI. PLoS Biology, 19(9): e3000923, pp. 1-18. doi:10.1371/journal.pbio.3000923.

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 Creators:
Chen, X1, 2, Author              
Jiang, Y, Author              
Choi, S1, 2, Author              
Pohmann, R2, 3, Author              
Scheffler, K2, 3, Author              
Kleinfeld, D, Author
Yu, X, Author              
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Current approaches to high-field functional MRI (fMRI) provide 2 means to map hemodynamics at the level of single vessels in the brain. One is through changes in deoxyhemoglobin in venules, i.e., blood oxygenation level-dependent (BOLD) fMRI, while the second is through changes in arteriole diameter, i.e., cerebral blood volume (CBV) fMRI. Here, we introduce cerebral blood flow-related velocity-based fMRI, denoted CBFv-fMRI, which uses high-resolution phase contrast (PC) MRI to form velocity measurements of flow. We use CBFv-fMRI in measure changes in blood velocity in single penetrating microvessels across rat parietal cortex. In contrast to the venule-dominated BOLD and arteriole-dominated CBV fMRI signals, CBFv-fMRI is comparable from both arterioles and venules. A single fMRI platform is used to map changes in blood pO2 (BOLD), volume (CBV), and velocity (CBFv). This combined high-resolution single-vessel fMRI mapping scheme enables vessel-specific hemodynamic mapping in animal models of normal and diseased states and further has translational potential to map vascular dementia in diseased or injured human brains with ultra-high-field fMRI.

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 Dates: 2021-09
 Publication Status: Published online
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 Identifiers: DOI: 10.1371/journal.pbio.3000923
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Title: PLoS Biology
  Other : PLoS Biol.
Source Genre: Journal
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Publ. Info: San Francisco, California, US : Public Library of Science
Pages: - Volume / Issue: 19 (9) Sequence Number: e3000923 Start / End Page: 1 - 18 Identifier: ISSN: 1544-9173
CoNE: https://pure.mpg.de/cone/journals/resource/111056649444170