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  DNA-based assembly of multi-compartment polymersome networks

Luo, R., Göpfrich, K., Platzman, I., & Spatz, J. P. (2020). DNA-based assembly of multi-compartment polymersome networks. Advanced Functional Materials, 2020: 2003480, pp. 1-10. doi:10.1002/adfm.202003480.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-FECC-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-FECD-6
Genre: Journal Article

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 Creators:
Luo, Rongcong1, Author              
Göpfrich, Kerstin1, Author              
Platzman, Ilia1, 2, Author              
Spatz, Joachim P.1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: assembly, DNA, microfluidics, polymersomes, synthetic biology
 Abstract: Polymersomes exhibit increased stability and reduced permeability compared to conventional lipid‐based compartments—making them an increasingly popular choice for the bottom‐up construction of synthetic cells. Here, the contraction and expansion of functionalized polymersome networks controlled by cholesterol‐tagged deoxyribonucleic acid (DNA) is demonstrated. Different types of block‐copolymer membranes are systematically screened to design a general framework for the self‐assembly of cholesterol‐tagged DNA into the polymersome membrane. Since the developed approach is DNA‐based, the individual symmetric and asymmetric functionalization of the inner and outer polymersome leaflets is possible, a feature which makes it unique in terms of anchoring flexibility and efficiency. In addition to the variety with regard to functionalization, the choice of DNA and temperature can also be used to manipulate the polymersome contact line and the polymersome bending energy. Overall, the strategy potentially allows for the unprecedented possibility to precisely control the contraction and expansion of polymersome network assembly.

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Language(s): eng - English
 Dates: 2020-07-072020-04-202020-09-06
 Publication Status: Published online
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/adfm.202003480
 Degree: -

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Title: Advanced Functional Materials
  Other : Adv. Funct. Mater.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH Verlag GmbH
Pages: - Volume / Issue: 2020 Sequence Number: 2003480 Start / End Page: 1 - 10 Identifier: ISSN: 1616-301X
CoNE: https://pure.mpg.de/cone/journals/resource/954925596563