CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters 
in peripheral nerves

Eichel, Maria A.; Gargareta, Vasiliki-Ilya; D’Este, Elisa; Fledrich, Robert; Kungl, Theresa; Buscham, Tobias J.; Lüders, Katja A.; Miracle, Cristina; Jung, Ramona B.; Distler, Ute; Kusch, Kathrin; Möbius, Wiebke; Hülsmann, Swen; Tenzer, Stefan; Nave, Klaus-Armin; Werner, Hauke B.

doi:10.1038/s41467-020-18172-7

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CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves

Eichel, M. A., Gargareta, V.-I., D’Este, E., Fledrich, R., Kungl, T., Buscham, T. J., et al. (2020). CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves. Nature Communications, 11(1): 4514 (2020), pp. 1-12. doi:10.1038/s41467-020-18172-7.

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Creators:
Eichel, Maria A., Author
Gargareta, Vasiliki-Ilya, Author
D’Este, Elisa¹, Author
Fledrich, Robert, Author
Kungl, Theresa, Author
Buscham, Tobias J., Author
Lüders, Katja A., Author
Miracle, Cristina, Author
Jung, Ramona B., Author
Distler, Ute, Author
Kusch, Kathrin, Author
Möbius, Wiebke, Author
Hülsmann, Swen, Author
Tenzer, Stefan, Author
Nave, Klaus-Armin, Author
Werner, Hauke B., Author

Affiliations:
1Max Planck Institute for Medical Research, Max Planck Society, ou_1125545

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Abstract: The velocity of nerve conduction is moderately enhanced by larger axonal diameters and potently sped up by myelination of axons. Myelination thus allows rapid impulse propagation with reduced axonal diameters; however, no myelin-dependent mechanism has been reported that restricts radial growth of axons. By label-free proteomics, STED-microscopy and cryo-immuno electron-microscopy we here identify CMTM6 (chemokine-like factor-like MARVEL-transmembrane domain-containing family member-6) as a myelin protein specifically localized to the Schwann cell membrane exposed to the axon. We find that disruption of Cmtm6-expression in Schwann cells causes a substantial increase of axonal diameters but does not impair myelin biogenesis, radial sorting or integrity of axons. Increased axonal diameters correlate with accelerated sensory nerve conduction and sensory responses and perturbed motor performance. These data show that Schwann cells utilize CMTM6 to restrict the radial growth of axons, which optimizes nerve function.

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Language(s): eng - English

Dates: Submitted: 2020-01-20Accepted: 2020-08-07Published Online: 2020-09-09

Publication Status: Published online

Pages: 12

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Rev. Type: Peer

Identifiers: URI: https://pubmed.ncbi.nlm.nih.gov/32908139/
DOI: 10.1038/s41467-020-18172-7

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Title: Nature Communications

Abbreviation : Nat. Commun.

Source Genre: Journal

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Publ. Info: London : Nature Publishing Group

Pages: - Volume / Issue: 11 (1) Sequence Number: 4514 (2020) Start / End Page: 1 - 12 Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723