English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Blue Light and Melanopsin Contribution to the Pupil Constriction in the Blind-spot, Parafovea and Periphery

Schilling, T., Soltanlou, M., Seshadri, Y., Nuerk, H.-C., & Bahmani, H. (2020). Blue Light and Melanopsin Contribution to the Pupil Constriction in the Blind-spot, Parafovea and Periphery. In F. Cabitza, A. Fred, & H. Gamboa (Eds.), BIOSTEC 2020: Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies (pp. 482-489). Setúbal, Portugal: Scitepress.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0006-FF4C-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-FF79-4
Genre: Conference Paper

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Schilling, T, Author
Soltanlou, M, Author
Seshadri, Y, Author
Nuerk, H-C, Author
Bahmani, H1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: Retinal photoreceptors modulate the pupil diameter to regulate retinal illumination. At early stage the pupil-response is formed by intrinsically-photosensitive-Retinal-Ganglion-Cells (ipRGCs) expressing melanopsin, activated by blue light. ipRGCs’ axons pass through the optic nerve head, corresponding to the blind-spot. No photoreceptors except melanopsin appear to exist in the blind-spot. Contributions of melanopsin to pupil constriction in absence of classical photoreceptors in the blind-spot is not fully understood. We investigated how blue light in the blind-spot changes melanopsin-pupil-response compared to parafovea and periphery. The Post-Illumination-Pupil-Response (PIPR) amplitude reflecting melanopsin was analyzed for standardized time windows (1s<1.7s, 1s>1.8s and 2–6s) and expressed as pupillary-change. Bayesian analysis showed a BF>3 that PIPR>1.8s for blind-spot and periphery is not different. At times 2s–6s, a t-test comparison in the blind-spot condition showed a sign ificantly larger PIPR to blue compared to red light, confirming a melanopsin-pupil-response in the blind-spot. Taken together, equivalent stimulation in the blind-spot and periphery revealed comparable PIPR, although there are no rods and cones in the blind-spot. In absence of classical photoreceptors in the blind-spot, melanopsin seems to be responsible for pupil constriction in similar manner as in the periphery, which supports the presence of melanopsin on the axons of ipRGCs.

Details

show
hide
Language(s):
 Dates: 2020
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.5220/0008972404820489
 Degree: -

Event

show
hide
Title: 13th International Conference on Health Informatics (HEALTHINF 2020)
Place of Event: Valletta, Malta
Start-/End Date: 2020-02-24 - 2020-02-26

Legal Case

show

Project information

show

Source 1

show
hide
Title: BIOSTEC 2020: Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies
Source Genre: Proceedings
 Creator(s):
Cabitza, F, Editor
Fred, A, Editor
Gamboa, H, Editor
Affiliations:
-
Publ. Info: Setúbal, Portugal : Scitepress
Pages: - Volume / Issue: 5 Sequence Number: - Start / End Page: 482 - 489 Identifier: ISBN: 978-989-758-398-8