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  Increased recruitment of domain general neural networks in language processing following Intensive Language-Action Therapy: fMRI evidence from people with chronic aphasia

Dreyer, F. R., Doppelbauer, L., Büscher, V., Arndt, V., Stahl, B., Lucchese, G., et al. (2020). Increased recruitment of domain general neural networks in language processing following Intensive Language-Action Therapy: fMRI evidence from people with chronic aphasia. American Journal of Speech-Language Pathology, 89. doi:10.1044/2020_ajslp-19-00150.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-0241-D Version Permalink: http://hdl.handle.net/21.11116/0000-0007-0245-9
Genre: Journal Article

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 Creators:
Dreyer, Felix R.1, 2, Author
Doppelbauer, Lea1, 3, 4, Author
Büscher, Verena1, Author
Arndt, Verena1, Author
Stahl, Benjamin5, 6, 7, 8, Author              
Lucchese, Guglielmo5, Author
Hauk, Olaf9, Author
Mohr, Bettina10, 11, Author
Pulvermüller, Friedemann1, 2, 3, 4, Author
Affiliations:
1Brain Language Laboratory, Department of Philosophy and Humanities, FU Berlin, Germany, ou_persistent22              
2Cluster of Excellence Matters of Activity, Humboldt University Berlin, Germany, ou_persistent22              
3Einstein Center for Neurosciences Berlin (ECN), Berlin, Germany, ou_persistent22              
4Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
5Department of Neurology, Department of Neurology, Germany, ou_persistent22              
6Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
7Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205649              
8Psychologische Hochschule Berlin, Germany, ou_persistent22              
9MRC Cognition and Brain Sciences Unit, Cambridge, United Kingdom, ou_persistent22              
10Centre for Neuropsychology and Intensive Language Therapy (ZeNIS), Berlin, Germany, ou_persistent22              
11Department Psychiatry, Charité University Medicine Berlin, Germany, ou_persistent22              

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 Abstract: Purpose This study aimed to provide novel insights into the neural correlates of language improvement following intensive language-action therapy (ILAT; also known as constraint-induced aphasia therapy). Method Sixteen people with chronic aphasia underwent clinical aphasia assessment (Aachen Aphasia Test [AAT]), as well as functional magnetic resonance imaging (fMRI), both administered before (T1) and after ILAT (T2). The fMRI task included passive reading of single written words, with hashmark strings as visual baseline. Results Behavioral results indicated significant improvements of AAT scores across therapy, and fMRI results showed T2-T1 blood oxygenation-level-dependent (BOLD) signal change in the left precuneus to be modulated by the degree of AAT score increase. Subsequent region-of-interest analysis of this precuneus cluster confirmed a positive correlation of T2-T1 BOLD signal change and improvement on the clinical aphasia test. Similarly, the entire default mode network revealed a positive correlation between T2-T1 BOLD signal change and clinical language improvement. Conclusion These results are consistent with a more efficient recruitment of domain-general neural networks in language processing, including those involved in attentional control, following aphasia therapy with ILAT.

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Language(s): eng - English
 Dates: 2020-01-202019-10-162020-04-162020-08-24
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1044/2020_ajslp-19-00150
Other: online ahead of print
PMID: 32830988
 Degree: -

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Project name : -
Grant ID : pu 97/15-1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft
Project name : -
Grant ID : pu 97/15-2
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft

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Title: American Journal of Speech-Language Pathology
Source Genre: Journal
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Publ. Info: Rockville, MD : American Speech-Language-Hearing Association
Pages: - Volume / Issue: 89 Sequence Number: - Start / End Page: - Identifier: ISSN: 1558-9110
CoNE: https://pure.mpg.de/cone/journals/resource/1558-9110