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  AuthentiCT: A model of ancient DNA damage to estimate the proportion of present-day DNA contamination

Peyrégne, S., & Peter, B. M. (2020). AuthentiCT: A model of ancient DNA damage to estimate the proportion of present-day DNA contamination. Genome Biology, 21:. doi:10.1186/s13059-020-02123-y.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0007-0542-9 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000C-0F81-2
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 作成者:
Peyrégne, Stéphane1, 著者                 
Peter, Benjamin M.2, 著者                 
所属:
1Genomes, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_2074331              
2Genetic Diversity through Space and Time, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_2559696              

内容説明

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キーワード: Contamination; Ancient DNA ; Deamination ; Damage patterns
 要旨: Contamination from present-day DNA is a fundamental issue when studying ancient DNA from historical or archaeological material, and quantifying the amount of contamination is essential for downstream analyses. We present AuthentiCT, a command-line tool to estimate the proportion of present-day DNA contamination in ancient DNA datasets generated from single-stranded DNA libraries. The prediction is based solely on the patterns of post-mortem damage observed on ancient DNA sequences. The method has the power to quantify contamination from as few as 10,000 mapped sequences, making it particularly useful for analysing specimens that are poorly preserved or for which little data is available.

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言語: eng - English
 日付: 2020-09-15
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1186/s13059-020-02123-y
 学位: -

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出版物 1

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出版物名: Genome Biology
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: -
ページ: - 巻号: 21 通巻号: 246 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 1474-760X