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  Glycans as immune checkpoints : removal of branched N-glycans enhances immune recognition preventing cancer progression

Silva, M. C., Fernandes, Â., Oliveira, M., Resende, C., Correia, A., de-Freitas-Junior, J. C. M., et al. (2020). Glycans as immune checkpoints: removal of branched N-glycans enhances immune recognition preventing cancer progression. Cancer Immunology Research, 8(11), 1407-1425. doi:10.1158/2326-6066.CIR-20-0264.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-0F43-E Version Permalink: http://hdl.handle.net/21.11116/0000-0007-810A-C
Genre: Journal Article

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 Creators:
Silva, Mariana C., Author
Fernandes, Ângela, Author
Oliveira, Maria, Author
Resende, Carlos, Author
Correia, Alexandra, Author
de-Freitas-Junior, Julio. Cesar M., Author
Lavelle, Aonghus, Author
Andrade-da-Costa, Jessica, Author
Leander, Magdalena, Author
Xavier-Ferreira, Helena, Author
Bessa, José, Author
Pereira, Carina, Author
Henrique, Rui M, Author
Carneiro, Fátima, Author
Dinis-Ribeiro, Mário, Author
Marcos-Pinto, Ricardo, Author
Lima, Margarida, Author
Lepenies, Bernd1, Author              
Sokol, Harry, Author
Machado, Jose C, Author
Vilanova, Manuel, AuthorPinho, Salomé S, Author more..
Affiliations:
1Bernd Lepenies, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863298              

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 Abstract: Tumor growth is accompanied with dramatic changes in the cellular glycome, such as the aberrant expression of complex branched N-glycans. However, it remains elusive the role of this pro-tumoral N-glycan in immune evasion and whether its removal contributes to enhancement of immune recognition and to unleash an antitumor immune response. We demonstrated that branched N-glycans are used by colorectal cancer (CRC) cells to escape immune recognition, instructing the creation of immunosuppressive networks through inhibition of IFNγ. The removal of this "glycan-mask" exposed immunogenic mannose glycans that potentiated immune recognition by DC-SIGN-expressing immune cells, resulting in an effective antitumor immune response. We revealed a glycoimmune checkpoint in CRC, highlighting the therapeutic efficacy of its deglycosylation to potentiate immune recognition and, thus, improving cancer immunotherapy.

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Language(s): eng - English
 Dates: 2020-09-152020
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1158/2326-6066.CIR-20-0264
BibTex Citekey: Silvacanimm.0264.2020
 Degree: -

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Title: Cancer Immunology Research
Source Genre: Journal
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Publ. Info: Philadelphia, Pa. : American Association for Cancer Research
Pages: - Volume / Issue: 8 (11) Sequence Number: - Start / End Page: 1407 - 1425 Identifier: ISSN: 2326-6066