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  Glycans as immune checkpoints : removal of branched N-glycans enhances immune recognition preventing cancer progression

Silva, M. C., Fernandes, Â., Oliveira, M., Resende, C., Correia, A., de-Freitas-Junior, J. C. M., et al. (2020). Glycans as immune checkpoints: removal of branched N-glycans enhances immune recognition preventing cancer progression. Cancer Immunology Research, 8(11), 1407-1425. doi:10.1158/2326-6066.CIR-20-0264.

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Silva, Mariana C., Autor
Fernandes, Ângela, Autor
Oliveira, Maria, Autor
Resende, Carlos, Autor
Correia, Alexandra, Autor
de-Freitas-Junior, Julio. Cesar M., Autor
Lavelle, Aonghus, Autor
Andrade-da-Costa, Jessica, Autor
Leander, Magdalena, Autor
Xavier-Ferreira, Helena, Autor
Bessa, José, Autor
Pereira, Carina, Autor
Henrique, Rui M, Autor
Carneiro, Fátima, Autor
Dinis-Ribeiro, Mário, Autor
Marcos-Pinto, Ricardo, Autor
Lima, Margarida, Autor
Lepenies, Bernd1, Autor           
Sokol, Harry, Autor
Machado, Jose C, Autor
Vilanova, Manuel, AutorPinho, Salomé S, Autor mehr..
Affiliations:
1Bernd Lepenies, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863298              

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 Zusammenfassung: Tumor growth is accompanied with dramatic changes in the cellular glycome, such as the aberrant expression of complex branched N-glycans. However, it remains elusive the role of this pro-tumoral N-glycan in immune evasion and whether its removal contributes to enhancement of immune recognition and to unleash an antitumor immune response. We demonstrated that branched N-glycans are used by colorectal cancer (CRC) cells to escape immune recognition, instructing the creation of immunosuppressive networks through inhibition of IFNγ. The removal of this "glycan-mask" exposed immunogenic mannose glycans that potentiated immune recognition by DC-SIGN-expressing immune cells, resulting in an effective antitumor immune response. We revealed a glycoimmune checkpoint in CRC, highlighting the therapeutic efficacy of its deglycosylation to potentiate immune recognition and, thus, improving cancer immunotherapy.

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Sprache(n): eng - English
 Datum: 2020-09-152020
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1158/2326-6066.CIR-20-0264
BibTex Citekey: Silvacanimm.0264.2020
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Titel: Cancer Immunology Research
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Philadelphia, Pa. : American Association for Cancer Research
Seiten: - Band / Heft: 8 (11) Artikelnummer: - Start- / Endseite: 1407 - 1425 Identifikator: ISSN: 2326-6066