English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  A FAK conundrum is solved: activation and organization of focal adhesion kinase at the plasma membrane

Brod, F., & Fässler, R. (2020). A FAK conundrum is solved: activation and organization of focal adhesion kinase at the plasma membrane. EMBO Journal, e106234. doi:10.15252/embj.2020106234.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0007-14EE-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-14EF-6
Genre: Journal Article

Files

show Files
hide Files
:
embj.2020106234.pdf (Publisher version), 205KB
Name:
embj.2020106234.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
©2020 The Authors
License:
-
:
10.15252-embj.2020106234Figure20201062340001.ppt (Supplementary material), 592KB
Name:
10.15252-embj.2020106234Figure20201062340001.ppt
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/vnd.ms-powerpoint / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Brod, Florian1, Author              
Fässler, Reinhard1, Author              
Affiliations:
1Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              

Content

show
hide
Free keywords: STRUCTURAL BASIS; DOMAINBiochemistry & Molecular Biology; Cell Biology;
 Abstract: Focal adhesion kinase (FAK) is a central mediator of cell adhesion, acting both as a scaffold and as catalytically active kinase. Acebronet al(2020) use cryo-electron microscopy (cryo-EM) to visualize the dramatic structural changes that occur uponFAKrecruitment to the plasma membrane, which releasesFAKautoinhibition and induces its oligomerization. Since activity control via autoinhibition and protein clustering are features also utilized by other focal adhesion (FA) proteins, they have moved center stage in the endeavor to understand the complex process of cell adhesion regulation.

Details

show
hide
Language(s): eng - English
 Dates: 2020-08-31
 Publication Status: Published online
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000564034900001
DOI: 10.15252/embj.2020106234
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: EMBO Journal
  Other : EMBO J.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Nature Publishing Group
Pages: - Volume / Issue: - Sequence Number: e106234 Start / End Page: - Identifier: ISSN: 0261-4189
CoNE: https://pure.mpg.de/cone/journals/resource/954925497061