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  CancerSim: A Cancer Simulation Package for Python 3

Opašić, L., Scott, J. G., Traulsen, A., & Fortmann-Grote, C. (2020). CancerSim: A Cancer Simulation Package for Python 3. The Journal of Open Source Software, 5(53): 2436. doi:10.21105/joss.02436.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-1522-B Version Permalink: http://hdl.handle.net/21.11116/0000-0007-1523-A
Genre: Journal Article

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10.21105.joss.02436.pdf (Publisher version), 156KB
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 Creators:
Opašić, Luka1, Author              
Scott, Jacob G., Author
Traulsen, Arne1, Author              
Fortmann-Grote, Carsten2, Author              
Affiliations:
1Department Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445641              
2Department Microbial Population Biology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2421699              

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Free keywords: CancerSim
 Abstract: Cancer is a group of complex diseases characterized by excessive cell proliferation, invasion, anddestruction of the surrounding tissue (Vinay Kumar,2017). Its high division and mutation rateslead to excessive genetic diversity among tumour cells (intra tumour genetic heterogeneity).As a consequence, tumours can adapt very efficiently to environmental pressures, in particularto cancer therapy (Turajlic, Sottoriva, Graham, & Swanton,2019). This process is known assomatic evolution of cancer.Throughout most of its existence a tumour is inaccessible to direct observation and experi-mental evaluation through genetic sequencing of tumour samples. Therefore, computationalmodelling can be useful to study many aspects of cancer. Examples where theoretical modelscan be of great use include (i) early carcinogenesis, as lesions are clinically observable whenthey already contain millions of cells, (ii) seeding of metastases, and (iii) cancer cell dormancy(Altrock, Liu, & Michor,2015).

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Language(s): eng - English
 Dates: 2020-05-252020-09-23
 Publication Status: Published online
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.21105/joss.02436
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Title: The Journal of Open Source Software
  Other : Journal of Open Source Software
  Abbreviation : JOSS
Source Genre: Journal
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Pages: - Volume / Issue: 5 (53) Sequence Number: 2436 Start / End Page: - Identifier: ISSN: 2475-9066
CoNE: https://pure.mpg.de/cone/journals/resource/2475-9066