English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Investigating the Structure of Neurotoxic Protein Aggregates Inside Cells.

Bäuerlein, F. J. B., Fernandez-Busnadiego, R., & Baumeister, W. (2020). Investigating the Structure of Neurotoxic Protein Aggregates Inside Cells. Trends in Cell Biology, 30(12), 951-966. doi:10.1016/j.tcb.2020.08.007.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
1-s2.0-S0962892420301677-main.pdf (Publisher version), 5MB
Name:
1-s2.0-S0962892420301677-main.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
© 2020 The Authors.
:
1-s2.0-S0962892420301677-mmc1.docx (Supplementary material), 44KB
Name:
1-s2.0-S0962892420301677-mmc1.docx
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/vnd.openxmlformats-officedocument.wordprocessingml.document / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Bäuerlein, Felix J. B.1, Author              
Fernandez-Busnadiego, Ruben1, Author              
Baumeister, Wolfgang1, Author              
Affiliations:
1Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565142              

Content

show
hide
Free keywords: cryo-electron tomography; electron microscopy; inclusion bodies; neurodegeneration; protein aggregation; super-resolution light microscopy
 Abstract: Neurodegenerative diseases affect the lives of millions of people across the world, being particularly prevalent in the aging population. Despite huge research efforts, conclusive insights into the disease mechanisms are still lacking. Therefore, therapeutic strategies are limited to symptomatic treatments. A common histopathological hallmark of many neurodegenerative diseases is the presence of large pathognomonic protein aggregates, but their role in the disease pathology is unclear and subject to controversy. Here, we discuss imaging methods allowing investigation of these structures within their cellular environment: conventional electron microscopy (EM), super-resolution light microscopy (SR-LM), and cryo-electron tomography (cryo-ET). Multidisciplinary approaches are key for understanding neurodegenerative diseases and may contribute to the development of effective treatments. For simplicity, we focus on huntingtin aggregates, characteristic of Huntington's disease. Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Details

show
hide
Language(s): eng - English
 Dates: 2020-092020-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: Dedicated to the memory of Professor Dr. rer. nat. Edmund Bäuerlein (1932–2019).
 Rev. Type: Peer
 Identifiers: ISI: 32981805
DOI: 10.1016/j.tcb.2020.08.007
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : FP7 GA ERC-2012-SyG_318987-ToPAG
Grant ID : 318987
Funding program : Funding Programme 7 (FP7)
Funding organization : European Commission (EC)
Project name : EXC 2067/1- 390729940
Grant ID : 390729940
Funding program : Germany’s Excellence Strategy
Funding organization : Deutsche Forschungsgemeinschaft

Source 1

show
hide
Title: Trends in Cell Biology
  Other : Trends Cell Biol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, UK : Elsevier Current Trends
Pages: - Volume / Issue: 30 (12) Sequence Number: - Start / End Page: 951 - 966 Identifier: ISSN: 0962-8924
CoNE: https://pure.mpg.de/cone/journals/resource/954925580131