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  Autoencoding T1 using MRzero for simultaneous sequence optimization and neural network training

Dang, H., Loktyushin, A., Glang, F., Herz, K., Doerfler, A., Schölkopf, B., et al. (2020). Autoencoding T1 using MRzero for simultaneous sequence optimization and neural network training. Magnetic Resonance Materials in Physics, Biology and Medicine, 33(Supplement 1): S03.03, S27-S28.

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Dang, HN, Author
Loktyushin, A1, Author              
Glang, F2, 3, Author              
Herz, K2, 3, Author              
Doerfler, A, Author
Schölkopf, B1, Author              
Scheffler, K2, 3, Author              
Maier, A, Author
Zaiss, M2, 3, Author              
1Dept. Empirical Inference, Max Planck Institute for Intelligent Systems, Max Planck Society, ou_1497647              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              


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 Abstract: Introduction: Previously we proposed a supervised learning approach to automatically generate MR sequences from scratch without providing sequence programming rules, called MRzero [1]. In the present work, we develop an auto-encoder for T1 by performing a joint optimization of sequence parameters and a neural network using MRzero. Subjects/methods: The fully differentiable MRI pipeline is simulated end-to-end with Bloch parameters as input and T1 as target. We utilize known operator learning [2] in the reconstruction to reduce the number of trainable parameters in our NN by keeping the adjoint formalism [1] as known operator in the image reconstruction. The T1 training dataset consist of ten T1 maps with matrix size 32 9 32. For each target sample a non-zero PD rectangle with matrix size 16 9 16 at varying spatial location with voxel-wise randomly assigned PD, T1, T2 and B0 is defined, resulting in a total training data size of 2560 samples. A three-hidden-layer multilayer perceptron is used for T1 quantification. The MR sequence is based on a 180 deg inversion prepared 2D FLASH sequence with matrix size 32 9 32, TR = 15 ms, TE = 8 ms, FA = 5 deg, repeated 6 times with varying TI and Trec. Together with the NN parameters, all TI and Trec times are optimized to find the best sequence for T1 mapping and are initialized with 0. Additionally, a penalty for longer times was applied to enforce shorter sequences. The optimization process (Fig. 1) interleaves the sequence and NN optimization after 50 and 5000 iterations, respectively. In total 500 iterations of sequence optimization are performed. Simultaneously optimized sequence parameters and trained NN are applied on a higher resolution with matrix size 126 9 126 and parallel imaging (GRAPPA acceleration factor 3) for in vivo measurements at 3T. Results/discussion: The T1 map of a healthy subject generated by the final optimized sequence is displayed in Fig. 2. Figure 3 shows the different stages of sequence optimization. The acquired T1 values of CSF, white matter and grey matter for later iterations match well to literature values at 3T [3]. A standard inversion recovery sequence was used as reference. The obtained maps match well with the reference, but the acquisition time could be reduced from 63.3 s to 19.2 s. Optimized TI and Trec times range from 0.5 s to 1.8 s and 0.5 s to 1.1 s, respectively. The simultaneous sequence optimization and NN training was performed solely on synthetic data at low resolution, but inference on higher resolution on in vivo data provided high quality T1 maps. Preliminary results at low resolution were shown in [1]. The T1 autoencoder is a proof-of-concept that can be extended also to multiparametric mapping—similar to MR fingerprinting—yielding PD, T1, and T2, as well as B1 and B0 inhomogeneity maps.


 Dates: 2020-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
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 Rev. Type: -
 Identifiers: DOI: 10.1007/s10334-020-00874-0
 Degree: -


Title: 37th Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2020)
Place of Event: Wien, Austria
Start-/End Date: 2020-09-30 - 2020-10-02

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Title: Magnetic Resonance Materials in Physics, Biology and Medicine
Source Genre: Journal
Publ. Info: Amsterdam : No longer published by Elsevier
Pages: - Volume / Issue: 33 (Supplement 1) Sequence Number: S03.03 Start / End Page: S27 - S28 Identifier: ISSN: 0968-5243
CoNE: https://pure.mpg.de/cone/journals/resource/954926245532