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  Evolutionary approaches to combat antibiotic resistance: opportunities and challenges for precision medicine

Merker, M., Tueffers, L., Vallier, M., Groth, E. E., Sonnenkalb, L., Unterweger, D., et al. (2020). Evolutionary approaches to combat antibiotic resistance: opportunities and challenges for precision medicine. Frontiers in immunology, 11: 1938. doi:10.3389/fimmu.2020.01938.

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Merker, Matthias, Author
Tueffers, Leif, Author
Vallier, Marie1, 2, Author           
Groth, Espen E., Author
Sonnenkalb, Lindsay, Author
Unterweger, Daniel1, Author           
Baines, John F.1, Author           
Niemann, Stefan, Author
Schulenburg, Hinrich3, Author           
Affiliations:
1Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              
2IMPRS for Evolutionary Biology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445639              
3Max Planck Fellow Group Antibiotic Resistance Evolution, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2600692              

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 Abstract: The rise of antimicrobial resistance (AMR) in bacterial pathogens is acknowledged by the WHO as a major global health crisis. It is estimated that in 2050 annually up to 10 million people will die from infections with drug resistant pathogens if no efficient countermeasures are implemented. Evolution of pathogens lies at the core of this crisis, which enables rapid adaptation to the selective pressures imposed by antimicrobial usage in both medical treatment and agriculture, consequently promoting the spread of resistance genes or alleles in bacterial populations. Approaches developed in the field of Evolutionary Medicine attempt to exploit evolutionary insight into these adaptive processes, with the aim to improve diagnostics and the sustainability of antimicrobial therapy. Here, we review the concept of evolutionary trade-offs in the development of AMR as well as new therapeutic approaches and their impact on host-microbiome-pathogen interactions. We further discuss the possible translation of evolution-informed treatments into clinical practice, considering both the rapid cure of the individual patients and the prevention of AMR.

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Language(s): eng - English
 Dates: 2020-06-012020-07-172020-08-27
 Publication Status: Published online
 Pages: -
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 Identifiers: DOI: 10.3389/fimmu.2020.01938
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Title: Frontiers in immunology
  Abbreviation : Front immunol
Source Genre: Journal
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Publ. Info: Lausanne : Frontiers Media
Pages: - Volume / Issue: 11 Sequence Number: 1938 Start / End Page: - Identifier: ISSN: 1664-3224
CoNE: https://pure.mpg.de/cone/journals/resource/1664-3224