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  Influence of ovarian hormones on value-based decision-making systems: Contribution to sexual dimorphisms in mental disorders

Ambrase, A., Lewis, C. A., Barth, C., & Derntl, B. (2021). Influence of ovarian hormones on value-based decision-making systems: Contribution to sexual dimorphisms in mental disorders. Frontiers in Neuroendocrinology, 60: 100873. doi:10.1016/j.yfrne.2020.100873.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-1F9C-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-1F9D-7
Genre: Journal Article

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 Creators:
Ambrase, Aiste1, 2, Author
Lewis, Carolin Annette1, 3, 4, Author              
Barth, Claudia5, Author
Derntl, Birgit1, 2, 6, 7, Author
Affiliations:
1Department for Psychiatry and Psychotherapy, Eberhard Karls University Tübingen, Germany, ou_persistent22              
2International Max Planck Research School for Cognitive and Systems Neuroscience, Tübingen, Germany, ou_persistent22              
3Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3230775              
4International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2616696              
5NORMENT Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Norway, ou_persistent22              
6Tübingen Neuro Campus, Eberhard Karls University Tübingen, Germany, ou_persistent22              
7LEAD Graduate School and Research Network, Eberhard Karls University Tübingen, Germany, ou_persistent22              

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Free keywords: Decision making; Depression; Dopamine; Estradiol; Menstrual cycle; Progesterone; Reward processing; Serotonin; Substance use disorder
 Abstract: Women and men exhibit differences in behavior when making value-based decisions. Various hypotheses have been proposed to explain these findings, stressing differences in functional lateralization of the brain, functional activation, neurotransmitter involvement and more recently, sex hormones. While a significant interaction of neurotransmitter systems and sex hormones has been shown for both sexes, decision-making in women might be particularly affected by variations of ovarian hormones. In this review we have gathered information from animal and human studies on how ovarian hormones affect decision-making processes in females by interacting with neurotransmitter systems at functionally relevant brain locations and thus modify the computation of decision aspects. We also review previous findings on impaired decision-making in animals and clinical populations with substance use disorder and depression, emphasizing how little we know about the role of ovarian hormones in aberrant decision-making.

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Language(s): eng - English
 Dates: 2020-07-282020-03-122020-09-152020-09-262021-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.yfrne.2020.100873
Other: online ahead of print
PMID: 32987043
 Degree: -

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Project name : -
Grant ID : DE2319/2-4
Funding program : -
Funding organization : German Research Foundation
Project name : -
Grant ID : DE2319/6-1
Funding program : -
Funding organization : German Research Foundation
Project name : -
Grant ID : DE2319/9-1
Funding program : -
Funding organization : German Research Foundation
Project name : -
Grant ID : #250358
Funding program : -
Funding organization : Research Council of Norway

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Title: Frontiers in Neuroendocrinology
Source Genre: Journal
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Publ. Info: Orlando, Fla. : Academic Press
Pages: - Volume / Issue: 60 Sequence Number: 100873 Start / End Page: - Identifier: ISSN: 0091-3022
CoNE: https://pure.mpg.de/cone/journals/resource/954922647073