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  Genetic diversity of HLA system in a population from Guerrero, Mexico

Juárez-Nicolás, F., Barquera, R., Martínez-Álvarez, J. C., Hernández-Zaragoza, D. I., Ortega-Yáñez, A., Arrieta-Bolaños, E., et al. (2020). Genetic diversity of HLA system in a population from Guerrero, Mexico. Human Immunology, 81(9), 550-552. doi:10.1016/j.humimm.2019.05.015.

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 Creators:
Juárez-Nicolás, Francisco, Author
Barquera, Rodrigo1, Author                 
Martínez-Álvarez, Julio César, Author
Hernández-Zaragoza, Diana Iraíz, Author
Ortega-Yáñez, Andrea, Author
Arrieta-Bolaños, Esteban, Author
Clayton, Stephen1, Author           
Bravo-Acevedo, Alicia, Author
Arrazola-García, María Araceli, Author
Immel, Alexander1, Author           
Juárez-Barreto, Vicencio, Author
Benítez-Arvizu, Gamaliel, Author
Vega-Martínez, María del Rosario, Author
García-Álvarez, Raquel, Author
Martínez-Bezies, Virginia, Author
Escutia-González, Ariadna Berenice, Author
Díaz-López, Rosario, Author
Guizar-López, Gregorio Ulises, Author
Salgado-Galicia, Norma, Author
Zúñiga, Joaquín, Author
Yunis, Edmond J., AuthorBekker-Méndez, Carolina, AuthorGranados, Julio, Author more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Guerrero, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 144 Mexicans from the state of Guerrero to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes in the state of Guerrero include eight Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in the state of Guerrero are Native American (61.36 ± 2.69 by ML; 54.17 of Native American haplotypes) and European (35.01 ± 4.59 by ML; 32.29 of European haplotypes), and a relatively low African genetic component (3.63 ± 2.38 by ML; 5.90 of African haplotypes).

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Language(s): eng - English
 Dates: 2019-06-042020-09
 Publication Status: Issued
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.humimm.2019.05.015
Other: 2241
 Degree: -

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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: 81 (9) Sequence Number: - Start / End Page: 550 - 552 Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912