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  Extrapyramidal plasticity predicts recovery after spinal cord injury

Huber, E., Patel, R., Hupp, M., Weiskopf, N., Chakravarty, M. M., & Freund, P. (2020). Extrapyramidal plasticity predicts recovery after spinal cord injury. Scientific Reports, 10: 14102. doi:10.1038/s41598-020-70805-5.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-2CBA-7 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-351F-6
Genre: Journal Article

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 Creators:
Huber, E.1, Author
Patel, R.2, 3, Author
Hupp, M.1, Author
Weiskopf, Nikolaus4, 5, Author           
Chakravarty, M. M.2, 3, 6, Author
Freund, Patrick1, 4, 7, 8, Author           
Affiliations:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
2Computational Brain Anatomy Laboratory (CoBrA Lab), Douglas Research Centre, McGill University, Montréal, QC, Canada, ou_persistent22              
3Department of Biomedical Engineering, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
5Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22              
6Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              
7Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
8Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              

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Free keywords: Biophysical models; Spinal cord diseases
 Abstract: Spinal cord injury (SCI) leads to wide-spread neurodegeneration across the neuroaxis. We explored trajectories of surface morphology, demyelination and iron concentration within the basal ganglia-thalamic circuit over 2 years post-SCI. This allowed us to explore the predictive value of neuroimaging biomarkers and determine their suitability as surrogate markers for interventional trials. Changes in markers of surface morphology, myelin and iron concentration of the basal ganglia and thalamus were estimated from 182 MRI datasets acquired in 17 SCI patients and 21 healthy controls at baseline (1-month post injury for patients), after 3, 6, 12, and 24 months. Using regression models, we investigated group difference in linear and non-linear trajectories of these markers. Baseline quantitative MRI parameters were used to predict 24-month clinical outcome. Surface area contracted in the motor (i.e. lower extremity) and pulvinar thalamus, and striatum; and expanded in the motor thalamus and striatum in patients compared to controls over 2-years. In parallel, myelin-sensitive markers decreased in the thalamus, striatum, and globus pallidus, while iron-sensitive markers decreased within the left caudate. Baseline surface area expansions within the striatum (i.e. motor caudate) predicted better lower extremity motor score at 2-years. Extensive extrapyramidal neurodegenerative and reorganizational changes across the basal ganglia-thalamic circuitry occur early after SCI and progress over time; their magnitude being predictive of functional recovery. These results demonstrate a potential role of extrapyramidal plasticity during functional recovery after SCI.

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Language(s): eng - English
 Dates: 2019-04-292020-08-052020-08-24
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41598-020-70805-5
PMID: 32839540
PMC: PMC7445170
 Degree: -

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Project name : -
Grant ID : WFL-CH-007/14
Funding program : -
Funding organization : Wings for Life
Project name : -
Grant ID : IRP- P158
Funding program : -
Funding organization : International Foundation for Research in Paraplegia (IRP)
Project name : Horizon 2020
Grant ID : 681094
Funding program : -
Funding organization : European Union
Project name : -
Grant ID : 15.0137
Funding program : -
Funding organization : Swiss State Secretariat for Education, Research and Innovation (SERI)
Project name : -
Grant ID : 616905
Funding program : Seventh Framework Programme
Funding organization : European Union
Project name : -
Grant ID : 01EW1711A & B
Funding program : -
Funding organization : Federal Ministry of Education and Research (BMBF)
Project name : -
Grant ID : 0915/Z/10/Z
Funding program : -
Funding organization : Wellcome Trust
Project name : -
Grant ID : PCEFP3_181362/1
Funding program : Eccellenza Professorial Fellowship
Funding organization : Schweizerischer Nationalfonds (SNF)

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 10 Sequence Number: 14102 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322