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  Extrapyramidal plasticity predicts recovery after spinal cord injury

Huber, E., Patel, R., Hupp, M., Weiskopf, N., Chakravarty, M. M., & Freund, P. (2020). Extrapyramidal plasticity predicts recovery after spinal cord injury. Scientific Reports, 10: 14102. doi:10.1038/s41598-020-70805-5.

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 Urheber:
Huber, E.1, Autor
Patel, R.2, 3, Autor
Hupp, M.1, Autor
Weiskopf, Nikolaus4, 5, Autor           
Chakravarty, M. M.2, 3, 6, Autor
Freund, Patrick1, 4, 7, 8, Autor           
Affiliations:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
2Computational Brain Anatomy Laboratory (CoBrA Lab), Douglas Research Centre, McGill University, Montréal, QC, Canada, ou_persistent22              
3Department of Biomedical Engineering, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
5Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22              
6Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              
7Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
8Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              

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 Zusammenfassung: Spinal cord injury (SCI) leads to wide-spread neurodegeneration across the neuroaxis. We explored trajectories of surface morphology, demyelination and iron concentration within the basal ganglia-thalamic circuit over 2 years post-SCI. This allowed us to explore the predictive value of neuroimaging biomarkers and determine their suitability as surrogate markers for interventional trials. Changes in markers of surface morphology, myelin and iron concentration of the basal ganglia and thalamus were estimated from 182 MRI datasets acquired in 17 SCI patients and 21 healthy controls at baseline (1-month post injury for patients), after 3, 6, 12, and 24 months. Using regression models, we investigated group difference in linear and non-linear trajectories of these markers. Baseline quantitative MRI parameters were used to predict 24-month clinical outcome. Surface area contracted in the motor (i.e. lower extremity) and pulvinar thalamus, and striatum; and expanded in the motor thalamus and striatum in patients compared to controls over 2-years. In parallel, myelin-sensitive markers decreased in the thalamus, striatum, and globus pallidus, while iron-sensitive markers decreased within the left caudate. Baseline surface area expansions within the striatum (i.e. motor caudate) predicted better lower extremity motor score at 2-years. Extensive extrapyramidal neurodegenerative and reorganizational changes across the basal ganglia-thalamic circuitry occur early after SCI and progress over time; their magnitude being predictive of functional recovery. These results demonstrate a potential role of extrapyramidal plasticity during functional recovery after SCI.

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Sprache(n): eng - English
 Datum: 2019-04-292020-08-052020-08-24
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1038/s41598-020-70805-5
PMID: 32839540
PMC: PMC7445170
 Art des Abschluß: -

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Projektname : -
Grant ID : WFL-CH-007/14
Förderprogramm : -
Förderorganisation : Wings for Life
Projektname : -
Grant ID : IRP- P158
Förderprogramm : -
Förderorganisation : International Foundation for Research in Paraplegia
Projektname : Horizon 2020
Grant ID : 681094
Förderprogramm : -
Förderorganisation : European Union
Projektname : -
Grant ID : 15.0137
Förderprogramm : -
Förderorganisation : Swiss State Secretariat for Education, Research and Innovation (SERI)
Projektname : Seventh Framework Programme
Grant ID : 616905
Förderprogramm : -
Förderorganisation : European Union
Projektname : -
Grant ID : 01EW1711A & B
Förderprogramm : -
Förderorganisation : Federal Ministry of Education and Research (BMBF)
Projektname : -
Grant ID : 0915/Z/10/Z
Förderprogramm : -
Förderorganisation : Wellcome Trust
Projektname : -
Grant ID : PCEFP3_181362/1
Förderprogramm : -
Förderorganisation : SNF Eccellenza Professorial Fellowship grant

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Titel: Scientific Reports
  Kurztitel : Sci. Rep.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: London, UK : Nature Publishing Group
Seiten: - Band / Heft: 10 Artikelnummer: 14102 Start- / Endseite: - Identifikator: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322