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  Superficial white matter imaging: Contrast mechanisms and whole-brain in vivo mapping

Kirilina, E., Helbling, S., Morawski, M., Pine, K., Reimann, K., Jankuhn, S., et al. (2020). Superficial white matter imaging: Contrast mechanisms and whole-brain in vivo mapping. Science Advances, 6(41): eaaz9281. doi:10.1126/sciadv.aaz9281.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-328B-4 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-45E0-8
Genre: Journal Article

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 Creators:
Kirilina, Evgeniya1, 2, Author           
Helbling, Saskia1, Author           
Morawski, Markus3, Author
Pine, Kerrin1, Author           
Reimann, Katja3, Author
Jankuhn, Steffen4, Author
Dinse, Juliane1, Author           
Deistung, Andreas5, 6, Author
Reichenbach, Jürgen R.5, Author
Trampel, Robert1, Author           
Geyer, Stefan1, Author           
Müller, Larissa7, Author
Jakubowski, Norbert7, 8, Author
Arendt, Thomas3, Author
Bazin, Pierre-Louis1, 9, Author           
Weiskopf, Nikolaus1, 4, 10, Author           
Affiliations:
1Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
2Center for Cognitive Neuroscience Berlin (CCNB), FU Berlin, Germany, ou_persistent22              
3Paul Flechsig Institute for Brain Research, University of Leipzig, Germany, ou_persistent22              
4Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22              
5Medical Physics Group, Department of Radiology, Friedrich Schiller University Jena, Germany, ou_persistent22              
6Department of Radiology, Martin Luther University Halle-Wittenberg, Germany, ou_persistent22              
7Federal Institute for Materials Research and Testing, Berlin, Germany, ou_persistent22              
8Spetec GmbH, Erding, Germany, ou_persistent22              
9Integrative Model-Based Cognitive Neuroscience Research Unit (IMCN), University of Amsterdam, Germany, ou_persistent22              
10Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              

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 Abstract: Superficial white matter (SWM) contains the most cortico-cortical white matter connections in the human brain encompassing the short U-shaped association fibers. Despite its importance for brain connectivity, very little is known about SWM in humans, mainly due to the lack of noninvasive imaging methods. Here, we lay the groundwork for systematic in vivo SWM mapping using ultrahigh resolution 7 T magnetic resonance imaging. Using biophysical modeling informed by quantitative ion beam microscopy on postmortem brain tissue, we demonstrate that MR contrast in SWM is driven by iron and can be linked to the microscopic iron distribution. Higher SWM iron concentrations were observed in U-fiber-rich frontal, temporal, and parietal areas, potentially reflecting high fiber density or late myelination in these areas. Our SWM mapping approach provides the foundation for systematic studies of interindividual differences, plasticity, and pathologies of this crucial structure for cortico-cortical connectivity in humans.

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Language(s): eng - English
 Dates: 2019-11-042020-08-262020-10-072020-10-07
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1126/sciadv.aaz9281
PMID: 33028535
 Degree: -

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Project name : -
Grant ID : FP7/2007-2013
Funding program : -
Funding organization : European Union
Project name : -
Grant ID : 616905
Funding program : -
Funding organization : European Research Council (ERC)
Project name : -
Grant ID : 01EW1711A and B
Funding program : -
Funding organization : Bundesministerium für Bildung und Forschung (BMBF)
Project name : Horizon 2020
Grant ID : 681094
Funding program : -
Funding organization : European Union
Project name : -
Grant ID : 15.0137
Funding program : -
Funding organization : Swiss State Secretariat for Education, Research and Innovation (SERI)
Project name : -
Grant ID : MO 2249/3-1; GE 2967/1-1; DE 2516/1-1
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : 18072
Funding program : -
Funding organization : Alzheimer-Forschung-Inititiative e.V.

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Title: Science Advances
  Other : Sci. Adv.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington : AAAS
Pages: - Volume / Issue: 6 (41) Sequence Number: eaaz9281 Start / End Page: - Identifier: ISSN: 2375-2548
CoNE: https://pure.mpg.de/cone/journals/resource/2375-2548