Superficial white matter imaging: Contrast mechanisms and whole-brain in vivo 
mapping

Kirilina, Evgeniya; Helbling, Saskia; Morawski, Markus; Pine, Kerrin; Reimann, Katja; Jankuhn, Steffen; Dinse, Juliane; Deistung, Andreas; Reichenbach, Jürgen R.; Trampel, Robert; Geyer, Stefan; Müller, Larissa; Jakubowski, Norbert; Arendt, Thomas; Bazin, Pierre-Louis; Weiskopf, Nikolaus

doi:10.1126/sciadv.aaz9281

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Superficial white matter imaging: Contrast mechanisms and whole-brain in vivo mapping

Kirilina, E., Helbling, S., Morawski, M., Pine, K., Reimann, K., Jankuhn, S., Dinse, J., Deistung, A., Reichenbach, J. R., Trampel, R., Geyer, S., Müller, L., Jakubowski, N., Arendt, T., Bazin, P.-L., & Weiskopf, N. (2020). Superficial white matter imaging: Contrast mechanisms and whole-brain in vivo mapping. Science Advances, 6(41):. doi:10.1126/sciadv.aaz9281.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0007-328B-4 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0007-328E-1

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作成者:
Kirilina, Evgeniya^{1, 2}, 著者
Helbling, Saskia¹, 著者
Morawski, Markus³, 著者
Pine, Kerrin¹, 著者
Reimann, Katja³, 著者
Jankuhn, Steffen⁴, 著者
Dinse, Juliane¹, 著者
Deistung, Andreas^{5, 6}, 著者
Reichenbach, Jürgen R.⁵, 著者
Trampel, Robert¹, 著者
Geyer, Stefan¹, 著者
Müller, Larissa⁷, 著者
Jakubowski, Norbert^{7, 8}, 著者
Arendt, Thomas³, 著者
Bazin, Pierre-Louis^{1, 9}, 著者
Weiskopf, Nikolaus^{1, 4, 10}, 著者

所属:
1Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649
2Center for Cognitive Neuroscience Berlin (CCNB), FU Berlin, Germany, ou_persistent22
3Paul Flechsig Institute for Brain Research, University of Leipzig, Germany, ou_persistent22
4Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22
5Medical Physics Group, Department of Radiology, Friedrich Schiller University Jena, Germany, ou_persistent22
6Department of Radiology, Martin Luther University Halle-Wittenberg, Germany, ou_persistent22
7Federal Institute for Materials Research and Testing, Berlin, Germany, ou_persistent22
8Spetec GmbH, Erding, Germany, ou_persistent22
9Integrative Model-Based Cognitive Neuroscience Research Unit (IMCN), University of Amsterdam, Germany, ou_persistent22
10Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22

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要旨: Superficial white matter (SWM) contains the most cortico-cortical white matter connections in the human brain encompassing the short U-shaped association fibers. Despite its importance for brain connectivity, very little is known about SWM in humans, mainly due to the lack of noninvasive imaging methods. Here, we lay the groundwork for systematic in vivo SWM mapping using ultrahigh resolution 7 T magnetic resonance imaging. Using biophysical modeling informed by quantitative ion beam microscopy on postmortem brain tissue, we demonstrate that MR contrast in SWM is driven by iron and can be linked to the microscopic iron distribution. Higher SWM iron concentrations were observed in U-fiber-rich frontal, temporal, and parietal areas, potentially reflecting high fiber density or late myelination in these areas. Our SWM mapping approach provides the foundation for systematic studies of interindividual differences, plasticity, and pathologies of this crucial structure for cortico-cortical connectivity in humans.

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言語: eng - English

日付: 投稿: 2019-11-04受理: 2020-08-26オンライン出版: 2020-10-07出版: 2020-10-07

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識別子（DOI, ISBNなど）: DOI: 10.1126/sciadv.aaz9281
PMID: 33028535

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Grant ID : FP7/2007-2013

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Funding organization : European Union

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Grant ID : 616905

Funding program : ERC Grant

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Grant ID : 01EW1711A and B

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Funding organization : Bundesministerium für Bildung und Forschung

Project name : Horizon 2020

Grant ID : 681094

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Funding organization : European Union

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Grant ID : 15.0137

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Funding organization : Swiss State Secretariat for Education, Research and Innovation

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Grant ID : MO 2249/3-1

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Funding organization : German Research Foundation

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Grant ID : GE 2967/1-1

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Funding organization : German Research Foundation

Project name : -

Grant ID : DE 2516/1-1

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Funding organization : German Research Foundation

Project name : -

Grant ID : 18072

Funding program : -

Funding organization : Alzheimer-Forschung-Inititiative e.V.

出版物 1

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出版物名: Science Advances

その他 : Sci. Adv.

種別: 学術雑誌

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出版社, 出版地: Washington : AAAS

ページ: - 巻号: 6 (41) 通巻号: eaaz9281 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 2375-2548
CoNE: https://pure.mpg.de/cone/journals/resource/2375-2548

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