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  Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness

Valk, S. L., Xu, T., Margulies, D. S., Masouleh, S. K., Paquola, C., Goulas, A., et al. (2020). Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness. Science Advances, 6(39): eabb3417. doi:10.1126/sciadv.abb3417.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-3120-D Version Permalink: http://hdl.handle.net/21.11116/0000-0007-3121-C
Genre: Journal Article

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 Creators:
Valk, Sofie L.1, 2, 3, Author              
Xu, Ting4, Author
Margulies, Daniel S.4, 5, Author              
Masouleh, Shahrzad Kharabian1, 2, Author
Paquola, Casey6, Author
Goulas, Alexandros7, Author              
Kochunov, Peter8, Author
Smallwood, Jonathan9, Author              
Yeo, B. T. Thomas10, 11, 12, Author
Bernhardt, Boris C.6, Author              
Eickhoff, Simon B.1, 2, Author
Affiliations:
1Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
2Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22              
3Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
4Center for the Developing Brain, Child Mind Institute, New York, NY, USA, ou_persistent22              
5Institut du Cerveau et de la Moelle épinière (ICM), Université Paris-Sorbonne, France, ou_persistent22              
6McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada, ou_persistent22              
7Department of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
8Maryland Psychiatric Research Center (MPRC), University of Maryland School of Medicine, Baltimore, MD, USA, ou_persistent22              
9York Neuroimaging Centre, University of York, United Kingdom, ou_persistent22              
10Department of Electrical and Computer Engineering, Clinical Imaging Research Centre, National University of Singapore, ou_persistent22              
11Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA, ou_persistent22              
12NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, ou_persistent22              

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 Abstract: The topology of the cerebral cortex has been proposed to provide an important source of constraint for the organization of cognition. In a sample of twins (n = 1113), we determined structural covariance of thickness to be organized along both a posterior-to-anterior and an inferior-to-superior axis. Both organizational axes were present when investigating the genetic correlation of cortical thickness, suggesting a strong genetic component in humans, and had a comparable organization in macaques, demonstrating they are phylogenetically conserved in primates. In both species, the inferior-superior dimension of cortical organization aligned with the predictions of dual-origin theory, and in humans, we found that the posterior-to-anterior axis related to a functional topography describing a continuum of functions from basic processes involved in perception and action to more abstract features of human cognition. Together, our study provides important insights into how functional and evolutionary patterns converge at the level of macroscale cortical structural organization.

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Language(s): eng - English
 Dates: 2020-02-182020-08-042020-09-252020-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1126/sciadv.abb3417
PMID: 32978162
PMC: PMC7518868
 Degree: -

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Project name : -
Grant ID : R01MH094639-01
Funding program : -
Funding organization : National Institute of Mental Health
Project name : -
Grant ID : 1FDN2012-1
Funding program : -
Funding organization : Child Mind Institute
Project name : -
Grant ID : R01MH081218, R01MH083246, and R21MH084126
Funding program : -
Funding organization : National Institute of Mental Health
Project name : -
Grant ID : EI 816/21-1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft
Project name : -
Grant ID : R01-MH074457
Funding program : -
Funding organization : National Institute of Mental Health
Project name : Horizon 2020
Grant ID : 785907 & 945539
Funding program : -
Funding organization : European Union
Project name : -
Grant ID : NI17-039
Funding program : -
Funding organization : SickKids Foundation
Project name : -
Grant ID : 1304413
Funding program : -
Funding organization : National Sciences and Engineering Research Council of Canada
Project name : -
Grant ID : FDN-154298
Funding program : -
Funding organization : Canadian Institutes of Health Research

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Title: Science Advances
  Other : Sci. Adv.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington : AAAS
Pages: - Volume / Issue: 6 (39) Sequence Number: eabb3417 Start / End Page: - Identifier: ISSN: 2375-2548
CoNE: https://pure.mpg.de/cone/journals/resource/2375-2548