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キーワード:
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要旨:
We report the ligand-enabled C-H activation/olefination of free carboxylic acids in the gamma-position. Through an intramolecular Michael addition, delta-lactones are obtained as products. Two distinct ligand classes are identified that enable the challenging palladium-catalyzed activation of free carboxylic acids in the gamma-position. The developed protocol features a wide range of acid substrates and olefin reaction partners and is shown to be applicable on a preparatively useful scale. Insights into the underlying reaction mechanism obtained through kinetic studies are reported.
