Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Grade C molar-incisor pattern periodontitis subgingival microbial profile before and after treatment

Velsko, I. M., Harrison, P., Chalmers, N., Barb, J., Huang, H., Aukhil, I., et al. (2020). Grade C molar-incisor pattern periodontitis subgingival microbial profile before and after treatment. Journal of oral microbiology, 12(1): 1814674, pp. 1-13. doi:10.1080/20002297.2020.1814674.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Dateien

einblenden: Dateien
ausblenden: Dateien
:
shh2714.pdf (Verlagsversion), 3MB
Name:
shh2714.pdf
Beschreibung:
OA
OA-Status:
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Velsko, Irina Marie1, Autor           
Harrison, Peter, Autor
Chalmers, Natalia, Autor
Barb, Jennifer, Autor
Huang, Hong, Autor
Aukhil, Ikramuddin, Autor
Shaddox, Luciana, Autor
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

Inhalt

einblenden:
ausblenden:
Schlagwörter: Aggressive periodontitis, subgingival microbiota, A.a., therapy, microarray
 Zusammenfassung: AIM: This study evaluated the influence of periodontal therapy on the microbiological profile of individuals with Grade C Molar-Incisor Pattern Periodontitis (C/MIP).

METHODS: Fifty-three African-American participants between the ages of 5–25, diagnosed with C/MIP were included. Patients underwent full mouth mechanical debridement with systemic antibiotics (metronidazole 250 mg + amoxicillin 500 mg, tid, 7 days). Subgingival samples were collected from a diseased and a healthy site from each individual prior to treatment and at 3, 6, 12, 18 and 24 months after therapy from the same sites. Samples were subjected to a 16S rRNA gene based-microarray.

RESULTS: Treatment was effective in reducing the main clinical parameters of disease. Aggregatibacter actinomycetemcomitans (A.a.) was the strongest species associated with diseased sites. Other species associated with diseased sites were Treponema lecithinolyticum and Tannerella forsythia. Species associated with healthy sites were Rothia dentocariosa/mucilaginosa, Eubacterium yurii, Parvimonas micra, Veillonella spp., Selenomonas spp., and Streptococcus spp. Overall, treatment was effective in strongly reducing A.a. and other key pathogens, as well as increasing health-associated species. These changes were maintained for at least 6 months.

CONCLUSIONS:Treatment reduced putative disease-associated species, particularly A.a., and shifted the microbial profile to more closely resemble a healthy-site profile. (Clinicaltrials.gov registration #NCT01330719).

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2020-09-13
 Publikationsstatus: Online veröffentlicht
 Seiten: 13
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: Introduction

Methods
- Demographics of the study population
- Clinical measurements
- Collection of bacterial subgingival biofilm
- Periodontal therapy
- DNA isolation and microarray analysis
- Statistical analyses

Results

Discussion
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1080/20002297.2020.1814674
Anderer: shh2714
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Journal of oral microbiology
  Kurztitel : J Oral Microbiol
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Bålsta : Co-Action Publishing
Seiten: - Band / Heft: 12 (1) Artikelnummer: 1814674 Start- / Endseite: 1 - 13 Identifikator: ISSN: 2000-2297
CoNE: https://pure.mpg.de/cone/journals/resource/2000-2297