English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Simultaneous voxel‐wise analysis of brain and spinal cord morphometry and microstructure within the SPM framework

Azzarito, M., Kyathanahally, S. P., Balbastre, Y., Seif, M., Blaiotta, C., Callaghan, M. F., et al. (2021). Simultaneous voxel‐wise analysis of brain and spinal cord morphometry and microstructure within the SPM framework. Human Brain Mapping, 42(1), 220-232. doi:10.1002/hbm.25218.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
Azzarito_2020.pdf (Publisher version), 3MB
Name:
Azzarito_2020.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Azzarito, Michela1, Author
Kyathanahally, Sreenath P.1, Author
Balbastre, Yaël2, Author
Seif, Maryam1, Author
Blaiotta, Claudia2, Author
Callaghan, Martina F.2, Author
Ashburner, John2, Author
Freund, Patrick1, 2, 3, 4, Author              
Affiliations:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
2Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
3Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
4Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              

Content

show
hide
Free keywords: Brain and spinal cord template; Multiparametric mapping; Neuraxis; SPM; Voxel‐wise analysis
 Abstract: To validate a simultaneous analysis tool for the brain and cervical cord embedded in the statistical parametric mapping (SPM) framework, we compared trauma-induced macro- and microstructural changes in spinal cord injury (SCI) patients to controls. The findings were compared with results obtained from existing processing tools that assess the brain and spinal cord separately. A probabilistic brain-spinal cord template (BSC) was generated using a generative semi-supervised modelling approach. The template was incorporated into the pre-processing pipeline of voxel-based morphometry and voxel-based quantification analyses in SPM. This approach was validated on T1-weighted scans and multiparameter maps, by assessing trauma-induced changes in SCI patients relative to controls and comparing the findings with the outcome from existing analytical tools. Consistency of the MRI measures was assessed using intraclass correlation coefficients (ICC). The SPM approach using the BSC template revealed trauma-induced changes across the sensorimotor system in the cord and brain in SCI patients. These changes were confirmed with established approaches covering brain or cord, separately. The ICC in the brain was high within regions of interest, such as the sensorimotor cortices, corticospinal tracts and thalamus. The simultaneous voxel-wise analysis of brain and cervical spinal cord was performed in a unique SPM-based framework incorporating pre-processing and statistical analysis in the same environment. Validation based on a SCI cohort demonstrated that the new processing approach based on the brain and cord is comparable to available processing tools, while offering the advantage of performing the analysis simultaneously across the neuraxis.

Details

show
hide
Language(s): eng - English
 Dates: 2020-08-052020-01-222020-09-092020-09-292021-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/hbm.25218
Other: epub 2020
PMID: 32991031
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : -
Grant ID : PCEFP3_181362/1
Funding program : -
Funding organization : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Project name : -
Grant ID : 091593/Z/10/Z
Funding program : -
Funding organization : Wellcome Trust
Project name : -
Grant ID : WFL‐CH‐007/14
Funding program : -
Funding organization : Wings for Life

Source 1

show
hide
Title: Human Brain Mapping
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 42 (1) Sequence Number: - Start / End Page: 220 - 232 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686