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  Serum BDNF levels correlate with regional cortical thickness in minor depression: A pilot study

Polyakova, M., Beyer, F., Mueller, K., Sander, C., Witte, A. V., Lampe, L., et al. (2020). Serum BDNF levels correlate with regional cortical thickness in minor depression: A pilot study. Scientific Reports, 10: 14524. doi:10.1038/s41598-020-71317-y.

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Polyakova, Maryna1, 2, 3, 4, Autor           
Beyer, Frauke1, 5, Autor           
Mueller, Karsten6, 7, Autor           
Sander, C.2, 3, Autor
Witte, A. Veronica1, 3, Autor           
Lampe, Leonie1, 3, Autor           
Rodrigues, F.3, 8, Autor
Riedel-Heller, S.3, 8, Autor
Kratzsch, J.3, 9, Autor
Hoffmann, K. T.10, Autor
Villringer, Arno1, 3, 11, Autor           
Schoenknecht, P.2, 3, 12, Autor
Schroeter, Matthias L.1, 3, 4, Autor           
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22              
3Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
4Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
5Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
6Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
7Method and Development Group Neural Data Science and Statistical Computing, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_3282987              
8Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
9Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
10Department of Neuroradiology, University of Leipzig, Germany, ou_persistent22              
11Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
12Department of Psychiatry and Psychotherapy, TU Dresden, Germany, ou_persistent22              

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 Zusammenfassung: Serum brain-derived neurotrophic factor (BDNF) reflects state changes in mood disorders. But its relation to brain changes in depression has rarely been investigated in humans. We assessed the association between serum BDNF, cortical thickness, or gray matter volume in 20 subjects with a minor depressive episode and 40 matched healthy subjects. Serum BDNF positively correlated with cortical thickness and volume in multiple brain regions in the minor depression group: the bilateral medial orbitofrontal cortex and rostral anterior cingulate cortex, left insula, and cingulum, right superior frontal gyrus, and other regions-regions typically affected by major depression. Interestingly, these correlations were driven by subjects with first episode depression. There was no significant association between these imaging parameters and serum BDNF in the healthy control group. Interaction analyses supported this finding. Our findings point to a specific association between serum BDNF and magnetic resonance imaging parameters in first-episode minor depression in a region- and condition-dependent manner. A positive correlation between serum BDNF and structural gray matter estimates was most consistently observed for cortical thickness. We discuss why cortical thickness should be preferred to volumetric estimates for such analyses in future studies. Results of our pilot study have to be proven in future larger-scale studies yielding higher statistical power.

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Sprache(n): eng - English
 Datum: 2020-03-062020-08-102020-09-03
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1038/s41598-020-71317-y
PMID: 32883977
PMC: PMC7471294
 Art des Abschluß: -

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Projektname : -
Grant ID : -
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Förderorganisation : LIFE-Leipzig Research Center for Civilization Diseases, Universitat Leipzig
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : 713-241202; 14505/2470; 14575/2470
Förderprogramm : -
Förderorganisation : Free State of Saxony
Projektname : International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity (IMPRS NeuroCom)
Grant ID : -
Förderprogramm : -
Förderorganisation : Max Planck Society
Projektname : -
Grant ID : SCHR 774/5-1
Förderprogramm : -
Förderorganisation : German Research Foundation (DFG)
Projektname : German Consortium for Frontotemporal Lobar Degeneration
Grant ID : -
Förderprogramm : -
Förderorganisation : German Federal Ministry of Education and Research (BMBF)
Projektname : -
Grant ID : PDF-IRG-1307
Förderprogramm : -
Förderorganisation : Parkinson's Disease Foundation
Projektname : -
Grant ID : MJFF-11362
Förderprogramm : -
Förderorganisation : Michael J. Fox Foundation (MJFF)

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Titel: Scientific Reports
  Kurztitel : Sci. Rep.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: London, UK : Nature Publishing Group
Seiten: - Band / Heft: 10 Artikelnummer: 14524 Start- / Endseite: - Identifikator: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322