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  Serum BDNF levels correlate with regional cortical thickness in minor depression: A pilot study

Polyakova, M., Beyer, F., Mueller, K., Sander, C., Witte, A. V., Lampe, L., Rodrigues, F., Riedel-Heller, S., Kratzsch, J., Hoffmann, K. T., Villringer, A., Schoenknecht, P., & Schroeter, M. L. (2020). Serum BDNF levels correlate with regional cortical thickness in minor depression: A pilot study. Scientific Reports, 10:. doi:10.1038/s41598-020-71317-y.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0007-3461-1 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000D-3245-D
資料種別: 学術論文

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Polyakova_2020.pdf (出版社版), 2MB
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https://hdl.handle.net/21.11116/0000-0007-3463-F
ファイル名:
Polyakova_2020.pdf
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Gold
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公開
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application/pdf / [MD5]
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CCライセンス:
https://creativecommons.org/licenses/by/4.0/

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作成者

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 作成者:
Polyakova, Maryna1, 2, 3, 4, 著者           
Beyer, Frauke1, 5, 著者           
Mueller, Karsten6, 7, 著者           
Sander, C.2, 3, 著者
Witte, A. Veronica1, 3, 著者           
Lampe, Leonie1, 3, 著者           
Rodrigues, F.3, 8, 著者
Riedel-Heller, S.3, 8, 著者
Kratzsch, J.3, 9, 著者
Hoffmann, K. T.10, 著者
Villringer, Arno1, 3, 11, 著者           
Schoenknecht, P.2, 3, 12, 著者
Schroeter, Matthias L.1, 3, 4, 著者           
所属:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22              
3Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
4Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
5Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
6Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
7Method and Development Group Neural Data Science and Statistical Computing, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_3282987              
8Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
9Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
10Department of Neuroradiology, University of Leipzig, Germany, ou_persistent22              
11Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
12Department of Psychiatry and Psychotherapy, TU Dresden, Germany, ou_persistent22              

内容説明

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キーワード: -
 要旨: Serum brain-derived neurotrophic factor (BDNF) reflects state changes in mood disorders. But its relation to brain changes in depression has rarely been investigated in humans. We assessed the association between serum BDNF, cortical thickness, or gray matter volume in 20 subjects with a minor depressive episode and 40 matched healthy subjects. Serum BDNF positively correlated with cortical thickness and volume in multiple brain regions in the minor depression group: the bilateral medial orbitofrontal cortex and rostral anterior cingulate cortex, left insula, and cingulum, right superior frontal gyrus, and other regions-regions typically affected by major depression. Interestingly, these correlations were driven by subjects with first episode depression. There was no significant association between these imaging parameters and serum BDNF in the healthy control group. Interaction analyses supported this finding. Our findings point to a specific association between serum BDNF and magnetic resonance imaging parameters in first-episode minor depression in a region- and condition-dependent manner. A positive correlation between serum BDNF and structural gray matter estimates was most consistently observed for cortical thickness. We discuss why cortical thickness should be preferred to volumetric estimates for such analyses in future studies. Results of our pilot study have to be proven in future larger-scale studies yielding higher statistical power.

資料詳細

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言語: eng - English
 日付: 2020-03-062020-08-102020-09-03
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子（DOI, ISBNなど）: DOI: 10.1038/s41598-020-71317-y
PMID: 32883977
PMC: PMC7471294
 学位: -

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訴訟

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Project information

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Project name : -
Grant ID : -
Funding program : -
Funding organization : LIFE-Leipzig Research Center for Civilization Diseases, Universitat Leipzig
Project name : -
Grant ID : -
Funding program : -
Funding organization : European Commission (EC)
Project name : -
Grant ID : 713-241202; 14505/2470; 14575/2470
Funding program : -
Funding organization : Free State of Saxony
Project name : International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity (IMPRS NeuroCom)
Grant ID : -
Funding program : -
Funding organization : Max Planck Society
Project name : -
Grant ID : SCHR 774/5-1
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : German Consortium for Frontotemporal Lobar Degeneration
Grant ID : -
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : -
Grant ID : PDF-IRG-1307
Funding program : -
Funding organization : Parkinson's Disease Foundation
Project name : -
Grant ID : MJFF-11362
Funding program : -
Funding organization : Michael J. Fox Foundation (MJFF)

出版物 1

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出版物名: Scientific Reports
  省略形 : Sci. Rep.
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: London, UK : Nature Publishing Group
ページ: - 巻号: 10 通巻号: 14524 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322