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  Serial synchrotron crystallography for time-resolved structural biology

Pearson, A. R., & Mehrabi, P. (2020). Serial synchrotron crystallography for time-resolved structural biology. Current Opinion in Structural Biology, 65, 168-174. doi:10.1016/j.sbi.2020.06.019.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0007-37A8-E Versions-Permalink: https://hdl.handle.net/21.11116/0000-000B-C080-A
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This is an open access article under the CC BY-NC-ND license.
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2020
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© the Author(s). Published by Elsevier Ltd.
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 Urheber:
Pearson, A. R.1, Autor
Mehrabi, P.2, Autor           
Affiliations:
1Institute for Nanostructure and Solid State Physics, Hamburg Centre for Ultrafast Imaging, Universität Hamburg, CFEL, ou_persistent22              
2Miller Group, Atomically Resolved Dynamics Department, Max Planck Institute for the Structure and Dynamics of Matter, Max Planck Society, ou_1938288              

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 Zusammenfassung: The current state-of-the-art experiments in time-resolved structural biology are undoubtedly the recent extremely impressive results that are emerging from XFEL-based experiments. However, there is a large range of macromolecular systems where the biological interest is predominantly in the slower dynamics (μs–s), that produce well diffracting microcrystals, and for which synchrotron-based experiments are extremely well suited. The combination of microfocus X-ray beams and the development of a range of sample delivery platforms has now made routine millisecond time-resolved experiments at microfocus macromolecular crystallography beamlines a real possibility and is driving development of dedicated endstations for time-resolved serial synchrotron crystallography.

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Sprache(n): eng - English
 Datum: 2020-102020-12
 Publikationsstatus: Erschienen
 Seiten: 7
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Interne Begutachtung
 Identifikatoren: DOI: 10.1016/j.sbi.2020.06.019
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Projektname : PM is supported by the Max Planck Society as well as a Joachim Herz Stiftung add-on fellowship and was the recipient of an Alexander von Humboldt-Stiftung postdoctoral research award. ARP is supported by the Clusters of Excellence ‘The Hamburg Centre for Ultrafast Imaging’ (EXC 1074) and ‘CUI: Advanced Imaging of Matter’ (EXC 2056) of the Deutsche Forschungsgemeinschaft. The development of the T-REXX TR-SSX endstation is supported by the BMBF (‘Verbundforschung’, 05K16GU1 and 05K19GU1). We thank David von Stetten for critical feedback on the manuscript.
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Titel: Current Opinion in Structural Biology
  Andere : Curr. Opin. Struct. Biol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Amsterdam : Elsevier
Seiten: - Band / Heft: 65 Artikelnummer: - Start- / Endseite: 168 - 174 Identifikator: ISSN: 0959-440X
CoNE: https://pure.mpg.de/cone/journals/resource/954925578067