English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Magnetite-arginine nanoparticles as a multifunctional biomedical tool

Reichel, V., Matuszak, J., Bente, K., Heil, T., Kraupner, A., Dutz, S., et al. (2020). Magnetite-arginine nanoparticles as a multifunctional biomedical tool. Nanomaterials, 10(10): 2014. doi:10.3390/nano10102014.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
article.pdf (Publisher version), 5MB
Name:
article.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-

Locators

show

Creators

show
hide
 Creators:
Reichel, Victoria1, Author              
Matuszak, Jasmin, Author
Bente, Klaas1, Author              
Heil, Tobias2, Author              
Kraupner, Alexander, Author
Dutz, Silvio, Author
Cicha, Iwona, Author
Faivre, Damien1, Author              
Affiliations:
1Damien Faivre, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863290              
2Nadezda V. Tarakina, Kolloidchemie, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2522693              

Content

show
hide
Free keywords: iron oxide; nanoparticle; theranostics; MRI; hyperthermia
 Abstract: Iron oxide nanoparticles are a promising platform for biomedical applications, both in terms of diagnostics and therapeutics. In addition, arginine-rich polypeptides are known to penetrate across cell membranes. Here, we thus introduce a system based on magnetite nanoparticles and the polypeptide poly-l-arginine (polyR-Fe3O4). We show that the hybrid nanoparticles exhibit a low cytotoxicity that is comparable to Resovistreg;, a commercially available drug. PolyR-Fe3O4 particles perform very well in diagnostic applications, such as magnetic particle imaging (1.7 and 1.35 higher signal respectively for the 3rd and 11th harmonic when compared to Resovistreg;), or as contrast agents for magnetic resonance imaging (R2/R1 ratio of 17 as compared to 11 at 0.94 T for Resovistreg;). Moreover, these novel particles can also be used for therapeutic purposes such as hyperthermia, achieving a specific heating power ratio of 208 W/g as compared to 83 W/g for Feridexreg;, another commercially available product. Therefore, we envision such materials to play a role in the future theranostic applications, where the arginine ability to deliver cargo into the cell can be coupled to the magnetite imaging properties and cancer fighting activity.

Details

show
hide
Language(s): eng - English
 Dates: 2020-10-132020
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3390/nano10102014
BibTex Citekey: nano10102014
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nanomaterials
  Abbreviation : Nanomater.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Basel, Schweiz : MDPI
Pages: - Volume / Issue: 10 (10) Sequence Number: 2014 Start / End Page: - Identifier: ISSN: 2079-4991