Help Privacy Policy Disclaimer
  Advanced SearchBrowse


  Network localization of alien limb in patients with corticobasal syndrome

Tetreault, A. M., Phan, T., Petersen, K. J., Claassen, D. O., Neth, B. J., Graff‐Radford, J., et al. (2020). Network localization of alien limb in patients with corticobasal syndrome. Annals of Neurology, ana.25901. doi:10.1002/ana.25901.

Item is


show hide
Genre: Journal Article


show Files




Tetreault, Aaron M.1, Author
Phan, Tony1, Author
Petersen, Kalen J.1, Author
Claassen, Daniel O.1, Author
Neth, Byran J.2, Author
Graff‐Radford, Jonathan2, Author
Albrecht, Franziska3, 4, Author
Fliessbach, Klaus4, 5, Author
Schneider, Anja4, 5, 6, Author
Synofzik, Matthis4, 7, Author
Diehl‐Schmid, Janine4, 8, Author
Otto, Markus4, 9, Author
Schroeter, Matthias L.3, 4, Author              
Darby, Richard Ryan4, Author
1Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA, ou_persistent22              
2Department of Neurology, Mayo Clinic, Rochester, NY, USA, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4German Consortium for Frontotemporal Lobar Degeneration (FTLD), Ulm, Germany, ou_persistent22              
5Department of Neurodegenerative Disease and Geriatric Psychiatry, University Hospital Bonn, Germany, ou_persistent22              
6German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany, ou_persistent22              
7Hertie-Institute for Clinical Brain Research, Eberhard Karls University Tübingen, Germany, ou_persistent22              
8Department of Psychiatry and Psychotherapy, TU Munich, Germany, ou_persistent22              
9Department of Neurology, Ulm University, Germany, ou_persistent22              


Free keywords: -
 Abstract: Objective: Perirolandic atrophy occurs in corticobasal syndrome (CBS) but is not specific versus progressive supranuclear palsy (PSP). There is heterogeneity in the locations of atrophy outside the perirolandic cortex and it remains unknown why atrophy in different locations would cause the same CBS-specific symptoms. In prior work, we used a wiring diagram of the brain called the human connectome to localize lesion-induced disorders to symptom-specific brain networks. Here, we use a similar technique termed "atrophy network mapping" to localize single-subject atrophy maps to symptom-specific brain networks. Methods: Single-subject atrophy maps were generated by comparing cortical thickness in patients with CBS versus controls. Next, we performed seed-based functional connectivity using a large normative connectome to determine brain regions functionally connected to each patient's atrophied locations. Results: Patients with CBS had perirolandic atrophy versus controls at the group level, but locations of atrophy in CBS were heterogeneous outside of the perirolandic cortex at the single-subject level (mean spatial correlation = 0.04). In contrast, atrophy occurred in locations functionally connected to the perirolandic cortex in all patients with CBS (spatial correlation = 0.66). Compared with PSP, patients with CBS had atrophy connected to a network of higher-order sensorimotor regions beyond perirolandic cortex, matching a CBS atrophy network from a recent meta-analysis. Finally, atrophy network mapping identified a symptom-specific network for alien limb, matching a lesion-induced alien limb network and a network associated with agency in healthy subjects. Interpretation: We identified a syndrome-specific network for CBS and symptom-specific network for alien limb using single-subject atrophy maps and the human connectome.


Language(s): eng - English
 Dates: 2020-09-102019-07-192020-09-112020-10-02
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/ana.25901
PMID: 32935385
Other: online ahead of print
 Degree: -



Legal Case


Project information

show hide
Project name : -
Grant ID : W81XWH‐19‐1‐0782
Funding program : -
Funding organization : U.S. Department of Defense

Source 1

Title: Annals of Neurology
Source Genre: Journal
Publ. Info: Boston : American Neurological Association
Pages: - Volume / Issue: - Sequence Number: ana.25901 Start / End Page: - Identifier: ISSN: 0364-5134
CoNE: https://pure.mpg.de/cone/journals/resource/954925523748